Browsing Molekulare Medizin by Advisor & Referee "Stadelmann-Nessler, Christine Prof. Dr."
Now showing items 1-11 of 11
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T cell-mediated ocular autoimmunity
(2025-03-07)Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system (CNS), leading to inflammatory lesions in the brain and spinal cord. The autoimmune process can affect both the gray and ... -
Long-term Replacement of Endogenous Microglia in Mice
(2024-12-19)Microglia are the resident immune cells of the central nervous system (CNS). They play pivotal roles in the development and homeostasis of the CNS and have been implicated in neurodegenerative disorders, such as Alzheimer´s ... -
Role of the cellular prion protein in the cellular internalization and the Tau-mediated toxicity
(2024-11-15)Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of Tau within the brain, leading to neuronal dysfunction and death. These diseases are classified into 3R tauopathies, 4R ... -
3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
Functional and structural analysis approaches for translational lung disease research.
(2024-06-13)Respiratory ailments continue to pose a formidable challenge to public health. The respiratory system is a delicate interplay of muscle contraction, pressure gradients and a large surface area with thin diffusion barriers ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
Characterization of myelin-specific autoantibodies in an EAE mouse model
(2023-10-02)Abstract Autoimmune diseases are caused by an attack of the immune system against own tissues, but the exact effector mechanisms may vary between individual diseases and are not yet fully understood. The autoimmune disease ... -
Alpha-synuclein-associated alterations at the synapse in models of Parkinson’s disease
(2023-08-16)Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is characterized by the typical motor features, and also by a multiplicity of non-motor symptoms. The main pathological hallmarks of PD ... -
Cholesterol metabolism in mouse models of Multiple Sclerosis
(2020-12-07)The primary origin of brain cholesterol is de novo synthesis due to limited entry peripheral cholesterol across the blood-brain barrier (BBB). Most if not all brain cells contribute to central nervous system (CNS) cholesterol ... -
Characterization of blood-brain barrier disruption in a focal model of neuromyelitis optica
(2015-11-20)Neuromyelitis optica (NMO) is a demyelinating autoimmune disease of the central nervous system (CNS), with serum anti-aquaporin4 (AQP4) antibodies (Ab) detected in the majority of patients. Binding of NMO-Ab to AQP4 results ...