Browsing Molekulare Medizin by Advisor & Referee "Thoms, Sven PD Dr."
Now showing items 1-5 of 5
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An integrative and translational assessment of altered atrial electrophysiology, calcium handling and contractility in patients with atrial fibrillation
(2020-11-18)Atrial fibrillation (AF) is the most prevalent sustained arrhythmia reported in clinical practice, and it is associated with deleterious outcomes such as stroke, that increase patient morbidity and mortality. Previous ... -
Mechanisms underlying low flow-low gradient aortic stenosis
(2020-11-09)Aortic stenosis (AS) remains the most common valvular disease in the elderly with an increasing prevalence, owing to the predominance of degenerative etiologies; hence, represents a major public health burden. The majority ... -
Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy
(2020-06-24)Doxorubicin (DOX) has been used for decades to treat hematopoietic and solid tumors, although, in a subset of cancer survivors, it causes cardiotoxicity decades after treatment. The mechanisms of anthracycline-induced ... -
Dysferlin in skeletal and heart muscle: from trafficking to therapy
(2017-09-19)Dysferlinopathies are a heterogeneous group of congenital muscle disorders characterized by late-onset muscular dystrophy and increased muscle prowess before onset of symptoms. Mutations in the DYSF gene encoding the protein ... -
Dysferlin and its role in the pathogenesis of muscular dystrophy
(2013-11-21)Dysferlin is a multi C2 domain protein that belongs to the ferlin family and is localized to the T-tubule system in skeletal muscle fibers. It is involved in skeletal muscle membrane repair, regeneration and T-tubule ...