Browsing Molekulare Medizin by Advisor & Referee "Thoms, Sven Prof. Dr."
Now showing items 1-4 of 4
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Mild production of reactive oxygen species reversibly affects the metabolism and function of the heart
(2023-01-25)Reactive oxygen species (ROS) are molecular oxygen derivatives that are produced as an attribute of aerobic life. The relationship between elevated levels of ROS and heart failure (HF) has been extensively studied. However, ... -
Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
Analysis of the peroxisomal malate/aspartate and lactate/pyruvate shuttle components and their metabolic function
(2022-05-19)Peroxisomes are responsible for several metabolic processes. Among the best known functions are the breakdown of peroxides like H2O2 and the catabolism of fatty acids by α- and β-oxidation. The proper function of these ... -
Peroxisomal calcium handling and homeostasis
(2022-04-26)Peroxisomes are ubiquitous cellular organelles in eukaryotes essential for metabolism. The close localization of peroxisomes with the sarcoplasmic reticulum and T-tubules is known from electron micrographs of rodent hearts. ...