Browsing Molekulare Medizin by Advisor & Referee "Weber, Martin Prof. Dr."
Now showing items 1-6 of 6
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Characterizing immunomodulatory properties of a novel therapeutic approach for multiple sclerosis - Inhibition of Bruton's tyrosine kinase
(2024-05-06)Multiple Sclerosis is a complex and challenging chronic disease of the central nervous system (CNS), characterized by inflammation, demyelination, and neurodegeneration. The depletion of B cells using anti-CD20 antibodies ... -
Investigating how peripheral myelin-specific antibodies contribute to central nervous system demyelination – implications for future therapeutical approaches
(2022-07-14)The discovery of peripheral autoantibodies against myelin oligodendrocyte glycoprotein (MOG) allowed the delineation of MOG antibody-associated disease (MOGAD) from other central nervous system (CNS) demyelinating disorders, ... -
Central nervous system intrinsic inflammation as driver and therapeutic target of progression in multiple sclerosis
(2022-01-25)Controlling disease progression in multiple sclerosis (MS) remains a major challenge. Progression of MS is defined as an increase in neurological disability occurring independently of relapses or focal MRI-detectable ... -
Proinflammatory CD20+ T cells: Their origin and therapeutic depletion in CNS-directed autoimmunity
(2021-04-06)Anti-CD20 antibody (ab) treatment exhibits an unprecedented therapeutic benefit in multiple sclerosis (MS). The very fact that B cell depletion is effective in a disease that was generally considered T cell-driven was ... -
Antibody-mediated initiation and lymphocyte-targeting therapies in CNS demyelinating disease
(2019-07-22)Multiple sclerosis is inflammatory central nervous system disease, characterised by areas of demyelination and axonal loss. The pathogenic mechanism behind the disease still remains unknown, however it is thought to be ... -
Functional characterization of B- and T lymphocytes after aCD20 treatment in two different EAE models
(2017-09-25)Multiple sclerosis (MS) is one of the most common causes of persisting disability in young adults. Its clinical course can be heterogeneous with a varying extent of inflammatory central nervous system (CNS) lesions, ...