Browsing Molekulare Medizin by Advisor & Referee "Wienands, Jürgen Prof. Dr."
Now showing items 1-19 of 19
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Subcellular compartmentalization of signal elements and their re-distribution in resting and activated B cells
(2024-09-19)BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process ... -
Characterizing immunomodulatory properties of a novel therapeutic approach for multiple sclerosis - Inhibition of Bruton's tyrosine kinase
(2024-05-06)Multiple Sclerosis is a complex and challenging chronic disease of the central nervous system (CNS), characterized by inflammation, demyelination, and neurodegeneration. The depletion of B cells using anti-CD20 antibodies ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells
(2021-08-10)Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in ... -
Analysis of the organization and signaling capacity of the membrane IgE during its interaction with CD19 and CD23 in B lymphocytes
(2021-07-27)The predominant allergy type I (hypersensitivity reaction type I) poses an increasing health issue in industrialized countries over the last decades. A key mediator in the pathogenesis of hypersensitivity or allergic ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
Proinflammatory CD20+ T cells: Their origin and therapeutic depletion in CNS-directed autoimmunity
(2021-04-06)Anti-CD20 antibody (ab) treatment exhibits an unprecedented therapeutic benefit in multiple sclerosis (MS). The very fact that B cell depletion is effective in a disease that was generally considered T cell-driven was ... -
Off the beaten path - An unbiased inventory of signal response elements in B cell receptor signaling
(2021-04-06)Signaling through the B cell antigen receptor (BCR) is indispensable for B lymphocyte maturation, activation and differentiation. Antigenic signal transduction thus constitutes a centerpiece of adaptive immunity and its ... -
The role of histone 2B monoubiquitination (H2Bub1) in HER2-driven mammary carcinoma
(2021-03-25)Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stage. Despite the advent of HER2-specific targeted therapies, a ... -
Novel protein-protein interactions contribute to the regulation of cardiac excitation and Ca2+ handling
(2021-02-01)Cardiac function is defined by the process of excitation and contraction. During this process, the electrical excitation of the surface membrane is coupled to Ca2+-ion release at the sarcoplasmic reticulum, resulting in ... -
The Role of Vav Family Guanine-Nucleotide Exchange Factors and their Substrates in B Cell Antigen Receptor Signaling
(2020-09-23)Stimulation of the B cell antigen receptor (BCR) triggers an intracellular signaling cascade through its integral signaling components Igα and Igβ. This signaling cascade involves several protein classes like kinases, ... -
Dynamics of Neutrophil Extracellular Trap (NET) Formation
(2019-12-03)Neutrophil granulocytes are the largest group of white blood cells and play a significant role in the innate immune system. With the discovery of a vast number of thus far unknown functions, neutrophil granulocytes became ... -
Antibody-mediated initiation and lymphocyte-targeting therapies in CNS demyelinating disease
(2019-07-22)Multiple sclerosis is inflammatory central nervous system disease, characterised by areas of demyelination and axonal loss. The pathogenic mechanism behind the disease still remains unknown, however it is thought to be ... -
Functional characterization of B- and T lymphocytes after aCD20 treatment in two different EAE models
(2017-09-25)Multiple sclerosis (MS) is one of the most common causes of persisting disability in young adults. Its clinical course can be heterogeneous with a varying extent of inflammatory central nervous system (CNS) lesions, ... -
IFNβ as regulator of CD14/TLR4-mediated microglial responses to CNS infection and damage
(2017-02-15)Microglia are the innate immune cells of the central nervous system (CNS). They are capable of sensing infection and damage through various receptors and consequently trigger an appropriate immune response. This includes ... -
Revisiting Erk signaling following B cell antigen receptor activation by different stimulatory agents
(2016-09-19)B cell antigen receptor (BCR) ligation leads to activation of a number of intracellular signaling events that decide the fate of the B cell and thus is a key event in humoral immunity. BCR activation is tightly controlled ... -
CIN85 in proximal and distant B cell antigen receptor signaling
(2016-03-15)B cell antigen receptor (BCR) signaling is pivotal in B cell development and initiation of humoral immune responses. In this process, numerous proteins are involved that interact with each other and build up a sophisticated ... -
Live Analysis of the Role of B cells in Experimental Autoimmune Encephalomyelitis
(2016-01-08)During the last years it has become increasingly clear that autoantigen-specific B cells play a pathogenic role in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, their ... -
Studying the Interactions of Cytotoxic T Cells with Neurons in vivo
(2013-12-13)The central nervous system (CNS) is considered as largely isolated from the immune system – a status referred to as “immune privilege”. But CNS-tissue is constantly surveyed by immune cells and can under certain circumstances, ...