Browsing Molekulare Medizin by Advisor & Referee "Zeisberg, Michael Prof. Dr."
Now showing items 1-8 of 8
-
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Mechanical regulation of cardiac fibroblasts.
(2021-08-09)Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into ... -
Untersuchungen zur Chemotherapieresistenz von H8N8-Tumorzellen nach Cyclophosphamid-, Doxorubicin- und 5-Fluouraciltherapie im syngenen WAP-T-Mammakarzinom-Mausmodell
(2019-10-18)In breast cancer patients, it is usually not the primary tumor that is the cause of death, but rather the development of locoregional or distant recurrence. Despite seemingly complete resection, some tumor cells often ... -
Role of ASXL1 in Tumorigenesis and EMT in Breast Cancer
(2017-06-22)Breast cancer is one of the types of cancer that occurs in women frequently and most of the cancer deaths are due to metastasis. During cancer metastasis, the tumor epithelial cells lose their cell-cell contacts, acquire ... -
The histone methyltransferase DOT1L is required for DNA damage recognition and repair
(2017-02-02)New effective combinational therapeutic strategies are an alternative choice for a successful translational study. Disruptor of telomeric silencing 1-like (DOT1L) is a histone 3 lysine 79 (H3K79) methyltransferase enzyme ... -
Analyse molekularer Marker und Signalwege in soliden Tumorzelllinien und ihre Bedeutung für die Tumorprogression und Metastasierung
(2016-06-01)The development of distant metastases is the main leading cause of cancer death and the crucial adverse event in cancer progression. The “Seed and Soil” hypothesis by Stephen Paget states that different cancer cells prefer ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ... -
Endothelial Transformation Related Protein 53 Deletion Promotes Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice
(2015-01-21)Background− Accumulation of transformation related protein 53 (p53), apoptotic cell death and rarefication of myocardial angiogenesis may be involved in the development of cardiac dysfunction during chronic pressure ...