Browsing Molekulare Medizin by Advisor & Referee "Zelarayán, Laura C. Prof. Dr."
Now showing items 1-4 of 4
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Determination of CaMKII and PKA role in PLN R14del functional phenotype
(2025-10-16)Phospholamban (PLN) is a 52-amino acid tail-anchored transmembrane protein and an essential regulator in the cardiac excitation-contraction coupling (ECC) involved in the regulation of the Sarcoendoplasmatic Reticulum ... -
Unraveling the Intercellular Interactions driven by Wnt-ß-catenin pathway in cardiac remodeling
(2025-08-29)Heart failure (HF) is the most common cardiovascular disease (CVD) and, despite significant pharmacological progress, it remains the leading cause of morbidity and mortality globally. One of the hallmarks of HF progression ... -
In vivo modelling of human central nervous system disease using chimeric mice
(2025-08-05)X-linked adrenoleukodystrophy (X-ALD) is a monogenic peroxisomal disorder caused by loss of function mutations in the ABCD1 gene, leading to impaired β-oxidation of very long-chain fatty acids (VLCFAs) and their pathological ... -
Functional and structural analysis approaches for translational lung disease research.
(2024-06-13)Respiratory ailments continue to pose a formidable challenge to public health. The respiratory system is a delicate interplay of muscle contraction, pressure gradients and a large surface area with thin diffusion barriers ...