Browsing Molekulare Medizin by Advisor "Alves, Frauke Prof. Dr."
Now showing items 1-8 of 8
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Cellular immunotherapy of pancreatic ductal adenocarcinoma: Discovery and evaluation of novel target candidates
(2021-03-19)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have achieved remarkable success in the ... -
Development and evaluation of new approaches for fluorescence-guided surgery and therapy of pancreatic ductal adenocarcinoma using orthotopic mouse models
(2017-07-11)Pancreatic cancer has the poorest survival rate of the most common types of cancers with a 5 year survival rate of only 3-5% after diagnosis. Since there has been no significant improvement in the clinical outcome for ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
In vivo imaging of the voltage-gated potassium channel Kv10.1 utilizing SPECT in combination with radiolabeled antibodies
(2015-11-19)The detection of tumors in an early phase of tumor development is an important achievement to improve the overall prognosis of the patient. Besides accurate information of tumor load and spread, the retrieval of the ... -
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
Untersuchungen zur Chemotherapieresistenz von H8N8-Tumorzellen nach Cyclophosphamid-, Doxorubicin- und 5-Fluouraciltherapie im syngenen WAP-T-Mammakarzinom-Mausmodell
(2019-10-18)In breast cancer patients, it is usually not the primary tumor that is the cause of death, but rather the development of locoregional or distant recurrence. Despite seemingly complete resection, some tumor cells often ...