Browsing Molekulare Medizin by Advisor "Zerr, Inga Prof. Dr."
Now showing items 1-6 of 6
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Cellular prion protein in Alzheimer’s disease: Molecular insights and behavior implications
(2024-01-11)Alzheimer’s disease (AD) poses a substantial and increasing challenge, particularly due to our aging population, and its underlaying pathophysiology remains a topic of ongoing debate. Cellular prion protein (PrPC) has ... -
Emerging role of RNA-binding proteins in sporadic and rapid progressive Alzheimer’s disease
(2020-04-07)Alzheimer’s disease (AD) is the most prevalent cause of dementia. Typically, AD is characterized as a slow progressive dementia with an average disease duration of eight years. Recently, a rapidly progressive variant of ... -
Optimization of the RT-QuIC in prion disease diagnostic
(2023-01-11)In the present work, we were interested in applying different recombinant prion proteins (rec PrP) as substrates in the real-time quaking-induced conversion (RT-QuIC) assay to improve the diagnostic accuracy in different ... -
Regional-dependent, comprehensive characterization of miRNA signatures in sporadic Creutzfeldt-Jakob Disease and early Alzheimer’s Disease-type neuropathology
(2019-10-09)The pathogenic mechanisms and the origins of neurodegenerative diseases remain unclear on molecular level. Increasing evidences postulate alterations in miRNA signatures as critical factor in pathogenesis, progression ... -
Seeding and structural varibility in α-synucleinopathies
(2019-06-12)In the present work, we were interested in applying the Real-time quaking-induced conversion (RT-QuIC) for the detection of the seeding activity of Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) brain derived ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ...