Browsing Molekulare Medizin by Referee "Bogeski, Ivan Prof Dr."
Now showing items 1-4 of 4
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Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Differentiation-Induced Rearrangement of the Mitochondrial Calcium Uniporter Complex Regulates T-Cell-Mediated Immunity
(2023-01-20)CD4+ T-cells are an important cell type involved in proper mediation of the human adaptive immune system. Activation of CD4+ T-cells is a regulated process which includes a tightly controlled cytosolic calcium (Ca2+) ... -
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
(2022-04-14)Melanoma is the deadliest of skin cancers and exhibits the highest level of brain tropism of all cancer types. Melanoma brain metastases (MBMs) are diagnosed in no less than 50 % of patients with stage IV melanoma, although ... -
Studying the role of coenzyme Q10 in mitochondrial calcium and redox signaling
(2022-06-30)Mitochondria can take up large amounts of calcium (Ca2+) in order to control the activity of several enzymes and their bioenergetics output. As a consequence of this metabolic flux, reactive oxygen species (ROS) are generated ...