Browsing Molekulare Medizin by Referee "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-20 of 26
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Analysis of the function of the IGF1R during the development and therapy of colorectal cancer
(2016-12-06)The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that is overexpressed in a variety of human malignancies, including colorectal cancer (CRC). In the present study, the role of the IGF1R during ... -
Effects of histone 3.3K27M-mutation on CREB binding protein (CBP/p300)- and bromodomain and extra terminal domain (BET) protein- mediated gene regulation in diffuse intrinsic pontine gliomas (DIPG)
(2023-04-25)Diffuse intrinsic pontine gliomas (DIPG) are incurable pediatric high-grade tumors. The majority of all DIPG carries a mutation in one of the histone 3 genes leading to a substitution of lysine 27 to methionine (H3 K27M) ... -
Endothelial Transformation Related Protein 53 Deletion Promotes Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice
(2015-01-21)Background− Accumulation of transformation related protein 53 (p53), apoptotic cell death and rarefication of myocardial angiogenesis may be involved in the development of cardiac dysfunction during chronic pressure ... -
Ex vivo und in vivo Modulation von Makrophagen und T-Zellen als therapeutisches Prinzip der aGvHD
(2015-10-15)Acute Graft-versus-Host disease (aGvHD) is a severe complication of hematopoietic stem cell transplantation. Glucocorticoids (GCs) are a mainstay of aGvHD therapy due to their potent anti-inflammatory and immunosuppressive ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Functional and diagnostic relevance of FGFR1-dependent signaling pathways in squamous cell lung cancer
(2020-09-22)Lung cancer continuous to be the leading cause of cancer-related death worldwide. A relatively new and effective approach of treating lung cancer is achieved through targeting specific molecular alterations in lung cancer ... -
Improving Therapies of Rhabdomyosarcoma
(2016-01-08)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and occurs as two major subtypes; embryonal (ERMS) and alveolar RMS (ARMS). Therapies of RMS typically combine surgical excision or local irradiation ... -
Interfering with critical steps of the viral replication cycle to diminish SARS-CoV-2 propagation
(2022-10-07)The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has so far infected more than 0.5 billion people worldwide, with at least 6.3 million deaths, and constitutes one of the largest global health ... -
Interplay of ARID1A and EGFR signaling in controlling acinar cell reprogramming in the pancreas
(2021-03-18)Based on a high degree of cellular plasticity and triggered by external (e.g. inflammation) or internal (e.g. oncogenic pressure) signals, pancreatic acinar cells can undergo reprogramming processes resulting in acinar-to-ductal ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
MiRNAs and tumor suppressors form a gene regulatory network to protect multiciliogenesis
(2019-01-10)Multiple motile cilia are present on specialized epithelial cells lining the airways, reproductive ducts, and brain ventricles. Cilia beating contributes to fluid movement and particle transport along the multiciliated ... -
Overcoming Cisplatin Resistance in Pancreatic Cancer
(2021-11-16)Pancreatic ductal adenocarcinoma (PDAC) is the most common species of pancreatic cancer with high lethality. Despite intensive research, no major therapy improvements have been achieved due to late-stage diagnosis and ... -
Physiological and molecular features of glucocorticoid actions in the gastrointestinal tract
(2015-04-14)Ever since their first successful application in the treatment of RA patients in the late 1950, GCs have been the gold standard for the treatment of multiple inflammatory and neoplastic diseases. There are, however, also ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ... -
Role of RAS signaling in Hedgehog-associated embryonal rhabdomyosarcoma
(2019-01-17)Rhabdomyosarcoma (RMS) are the most common pediatric soft tissue sarcomas. RMS of the embryonal subtype (ERMS) are characterized by high expression of markers of an activated Hedgehog (HH) signaling cascade, i.e. they ... -
Role of stromal SPARC in PDAC tumorigenesis and drug delivery
(2019-11-13)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors in humans. Median survival is around 12 months and is due to late diagnosis, early metastatic spread, and a high resistance towards available ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma
(2018-12-18)Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS, and especially the embryonal subtype (ERMS), show activation of Hedgehog (HH) signaling. In patients with Gorlin syndrome, ... -
The influence of valproic acid and the role of cyclin D2 in prostate cancer
(2016-10-11)Prostate cancer (PCa) is the most frequently new diagnosed cancer and the third leading cause of cancer-related deaths in men in Germany. Studies on possible agents for PCa therapy are indispensable since treatment options ...