Browsing Molekulare Medizin by Referee "Flügel, Alexander Prof. Dr."
Now showing items 1-7 of 7
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Cholesterol metabolism in mouse models of Multiple Sclerosis
(2020-12-07)The primary origin of brain cholesterol is de novo synthesis due to limited entry peripheral cholesterol across the blood-brain barrier (BBB). Most if not all brain cells contribute to central nervous system (CNS) cholesterol ... -
Exploring molecular patterns and determinants of melanoma cell susceptibility to natural killer cell cytotoxicity
(2020-07-16)Malignant melanoma is the deadliest form of skin cancer. Due to its genetic heterogeneity and high potential to metastasize, the treatment of melanoma is challenging. Despite the promising result of T-cell based therapeutic ... -
Gene-expression control in early and late-onset dementia
(2022-10-05)Mutations in genes that control epigenetic gene expression, especially the machinery that controls Histone 3 lysine 4 (H3K4me) methylation, are over-represented in intellectual disability disorders. It is mediated by both ... -
Impact of natalizumab therapy on human pathology and an animal model of multiple sclerosis (EAE) with special focus on B cell / plasma cell inflammation
(2014-03-13)Multiple sclerosis (MS) is considered to be a T cell-mediated demyelinating disease. However, there is increasing evidence for the involvement of B cells and plasma cells in MS pathogenesis: for instance, B cells and plasma ... -
Seeding and structural varibility in α-synucleinopathies
(2019-06-12)In the present work, we were interested in applying the Real-time quaking-induced conversion (RT-QuIC) for the detection of the seeding activity of Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) brain derived ... -
Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells
(2021-08-10)Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in ... -
The role of the astrocytic and microglial aryl hydrocarbon receptor in CNS demyelination
(2020-11-26)The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor which plays a key role in the regulation of immune and inflammatory responses. AhR expression in astrocytes and microglia was shown to limit ...