Browsing Molekulare Medizin by Referee "Hahn, Heidi Prof. Dr."
Now showing items 1-20 of 22
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Analyse molekularer Marker und Signalwege in soliden Tumorzelllinien und ihre Bedeutung für die Tumorprogression und Metastasierung
(2016-06-01)The development of distant metastases is the main leading cause of cancer death and the crucial adverse event in cancer progression. The “Seed and Soil” hypothesis by Stephen Paget states that different cancer cells prefer ... -
Cancer drugs targeting DNA replication: Molecular strategies to enhance specificity and efficacy
(2020-07-10)The DNA molecule stands at the center of cancer origin and treatment. Cancer cells are addicted to DNA mutations and DNA replication, therapeutic non-responders are often based on the rate of mutations and ability to ... -
Centrosome integrity as a determinant of replication stress
(2020-01-29)The centrosome functions as a microtubule-nucleating organelle for the mitotic spindle. Like the whole genome, centrosomes require accurate replication once per cell cycle. Here we show that the impairment of centrosome ... -
Establishing and application of a syngeneic cerebral metastasis mouse model
(2015-06-02)Metastases are a major cause of morbidity and mortality in breast cancer patients. However, current treatments are of limited efficiency because so far very little is known about the colonisation of breast cancer cells ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
Functional effects of the MICA-129 dimorphism on NK cell activity and association with the outcome of hematopoietic stem cell transplantation
(2014-05-06)The MHC class I chain-related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK) cell receptor NKG2D (NK group 2, member D). The single nucleotide polymorphism (SNP) at position 454 (A ... -
Interaction of hepatic uptake transporters with antineoplastic compounds and regulation of the expression of organic cation transporter 3 in renal carcinoma cells
(2015-02-06)The ability of a compound to exert its antineoplastic activity is determined by the amount of its accumulation inside the cell, a process largely dependent on the transporter proteins which are responsible for the passage ... -
Interfering with critical steps of the viral replication cycle to diminish SARS-CoV-2 propagation
(2022-10-07)The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has so far infected more than 0.5 billion people worldwide, with at least 6.3 million deaths, and constitutes one of the largest global health ... -
Interplays and feedback loops of oncogenic signaling pathways in B cell non-Hodgkin lymphoma
(2019-02-28)The B cell receptor (BCR) signaling, required for the survival and maturation of B cells, is one major deregulated pathway in B cell lymphomas. Several mutations are known to enhance the tonic BCR signal in Burkitt lymphomas ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ... -
Nuclear NFATc1/Smad3 complexes in Smad4-deficient pancreatic cancer
(2019-12-17)Until today, pancreatic ductal adenocarcinoma (PDAC) is characterized by its extremely high mortality rate and the lack of effective treatment strategies despite reinforced focus on the elucidation of underlying molecular ... -
Overcoming Cisplatin Resistance in Pancreatic Cancer
(2021-11-16)Pancreatic ductal adenocarcinoma (PDAC) is the most common species of pancreatic cancer with high lethality. Despite intensive research, no major therapy improvements have been achieved due to late-stage diagnosis and ... -
Role of RAS signaling in Hedgehog-associated embryonal rhabdomyosarcoma
(2019-01-17)Rhabdomyosarcoma (RMS) are the most common pediatric soft tissue sarcomas. RMS of the embryonal subtype (ERMS) are characterized by high expression of markers of an activated Hedgehog (HH) signaling cascade, i.e. they ... -
Targeting cell invason signaling to impede breast cancer metastasis
(2020-02-25)Breast cancer cell invasion is the initial step of the invasion-metastatic cascade, and approximately 90 % of all cancer-related deaths are due to currently incurable cancer metastasis (1). Unique features of tumor ... -
The interaction between Hedgehog/Patched and Ras signaling in Rhabdomyosarcoma
(2016-03-15)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. In children, the most common histological subtypes are embryonal RMS (ERMS) and alveolar RMS (ARMS). One feature of human RMS is aberrant Hedgehog ... -
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
(2023-02-23)MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ... -
The role of Pygo2 during intestinal tumor initiation and progression in vivo
(2016-05-12)Canonical Wnt signaling pathway is an essential regulator of embryonic development as well homeostasis of adult tissues and stem cell proliferation. Familial or sporadic mutations of genes of Wnt signaling components are ...