Dokumente Molekulare Medizin nach Gutachter "Johnsen, Steven A. Prof. Dr."
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Basic leucine zipper and W2 domain-containing protein 2 (BZW2): A novel cardiac WNT component
(2016-02-11)Tight regulation of the Wnt/β-catenin pathway is crucial not only at all stages of embryonic cardiac development but also for maintaining normal adult heart homeostasis. Indeed, activation of the Wnt/β-catenin signaling ... -
Elucidating the pathomechanism behind the neurocristopathy CHARGE syndrome
(2018-02-26)CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ... -
Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ... -
Functional relevance of spontaneous alternative splice variants of xeroderma pigmentosum genes: Prognostic marker for skin cancer risk and disease outcome?
(2017-05-05)The nucleotide excision repair (NER) pathway is a central DNA repair mechanism to repair a variety of bulky DNA lesions. Accumulation of these types of damage all over the genome results in the development of a cancer prone ... -
RNA methylation in Cardiac Hypertrophy and Heart Failure
(2020-11-06)Cardiovascular diseases (CVDs) are the leading cause of hospital admission and mortality worldwide. Heart failure (HF) is one of the most common CVDs and is characterized by a reduced cardiac function and left ventricular ... -
Stromal and epithelial mechanisms of chemotherapeutic resistance in pancreatic cancer
(2019-05-24)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of less than 8 %. Hallmarks of pancreatic cancer are extensive desmoplasia and strong resistance to standard chemotherapeutic ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Wnt-TCF7L2-dependent transcriptional and chromatin dynamics in cardiac regeneration, homeostasis and disease
(2018-11-12)Wnt/β-catenin-dependent signaling pathway is indispensible for cardiac development, becoming quiescent in the normal adult heart, and re-activated in both regenerative responses post-injury and in cardiac hypertrophy and ...