Browsing Molekulare Medizin by Referee "Katschinski, Dörthe Prof. Dr."
Now showing items 1-20 of 21
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Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ... -
Redox regulation of ryanodine receptor/Ca2+ release channels by NOX enzymes in hypertrophy and heart failure
(2022-05-10)Cardiac function is characterized by a rhythmic sequence of contraction and relaxation of cardiomyocytes driven by tightly controlled intracellular calcium release events. The cardiac ryanodine receptor type 2 calcium ... -
The role of CRISPLD1 in the transition to heart failure
(2022-01-21)Heart failure is a leading cause of death worldwide. It is defined as a condition in which the heart is unable to pump a sufficient amount of blood through the body to satisfy its oxygen need and can be caused by various ... -
Mechanical regulation of cardiac fibroblasts.
(2021-08-09)Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into ... -
Cellular and transcriptional profiling of hypoxic cells in the brain
(2021-07-08)Hypoxia is a critical regulator of the hypoxic response driving neurodevelop-ment, angiogenesis, hematopoiesis, and tissue regeneration. In the central nervous system, oxygen is a fundamental constituent of cellular ... -
Insights into early biogenesis steps of the human small mitochondrial ribosomal subunit
(2021-06-28)The rise of high-resolution cryo-EM structures of the human mitochondrial ribosome increased the understanding of the function and assembly. As the mitochondrial ribosome differs in structure and composition compared to ... -
Regulation of Respiratory Chain Supercomplex Formation and the Involvement of Rcf-proteins
(2021-06-03)The mitochondrial oxidative phosphorylation machinery is comprised by five individual complexes and arranged in supramolecular structures, so-called supercomplexes, as it is shown for complex I, III, IV and V. In yeast S. ... -
Novel protein-protein interactions contribute to the regulation of cardiac excitation and Ca2+ handling
(2021-02-01)Cardiac function is defined by the process of excitation and contraction. During this process, the electrical excitation of the surface membrane is coupled to Ca2+-ion release at the sarcoplasmic reticulum, resulting in ... -
RNA methylation in Cardiac Hypertrophy and Heart Failure
(2020-11-06)Cardiovascular diseases (CVDs) are the leading cause of hospital admission and mortality worldwide. Heart failure (HF) is one of the most common CVDs and is characterized by a reduced cardiac function and left ventricular ... -
From the centrosome to the nuclear envelope and beyond: insights into the role of CRM1 in adenoviral genome delivery
(2020-07-09)Adenoviruses (AdV) are DNA viruses that replicate in the nucleus of their host cell. Due to the limited coding capacity, they have to take advantage of cellular mechanisms in order to perform their infection cycle. During ... -
TET3 IMPACTS CARDIAC FIBROSIS PARTIALLY VIA REGULATION OF DNA DAMAGE RESPONSE
(2020-02-12)Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and inflammatory cytokines produced during fibrosis not only signal proliferative stimuli but ... -
Myofibroblast differentiation in hypoxia: a novel role for ArhGAP29
(2019-05-20)Myofibroblasts are crucial for normal wound healing and tissue remodelling and play an es-sential role in the pathogenesis of ischemic tissue fibrosis. Due to their contractile features, myofibroblasts support wound closure; ... -
Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Cellular responses mediated by the transcription factor STAT1 in murine inflammatory diseases
(2017-01-12)The intracellular transduction of interferon signals from the plasma membrane to the nucleus is mediated by signal transducer and activator of transcription 1 (STAT1) which acts in tetrameric form as a transcription factor ... -
The oxygen sensor PHD2 affects energy metabolism and cell function in macrophages
(2016-11-08)Macrophages are key players in the innate immune system and contribute significantly to inflammation in ischemic tissues, such as the infarcted heart. During inflammation, macrophages are involved in tissue remodeling, ... -
Physiology, metabolism and redox mechanisms in chronic cardiac volume overload
(2016-11-04)Chronic haemodynamic stress in the heart, induced by volume or pressure overload, contributes to cardiac dysfunction and heart failure and is associated with several human cardiovascular diseases (e.g. valvular heart ... -
An integrated approach using patient-specific induced pluripotent stem cells and protein biochemistry to study Vici syndrome associated cardiomyopathy
(2016-10-17)Vici syndrome is a rare autosomal recessive inherited multisystem disorder caused by mutations in EPG5. More than 80% of the patients with Vici syndrome suffer from cardiomyopathy. In this study, the induced pluripotent ... -
Control of cardiogenesis and homeostasis by cardiac fibroblasts
(2016-07-12)The mammalian heart is a complex multicellular organ which undergoes many critical changes during development and under pathological conditions. Cardiac fibroblasts (cFBs) represent the predominant non-myocyte population ... -
Characterization of cardiac progenitor cell activity in engineered heart muscle
(2016-06-21)The heart has been considered a post-mitotic organ incapable of regeneration upon injury. Recent findings suggest that the heart contains cardiac progenitor cells (CPCs) with the potential to give rise to cardiovascular ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ...