Browsing Molekulare Medizin by Referee "Meinecke, Michael Prof. Dr."
Now showing items 1-5 of 5
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Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
Investigating the role of neutral sphingomyelinases in membrane vesicle trafficking
(2022-07-21)Evidence collected over the years has established small extracellular vesicle (sEV) or exosome secretion as a novel paradigm for intercellular communication under both physiological and pathological conditions. SEVs ... -
Novel protein-protein interactions contribute to the regulation of cardiac excitation and Ca2+ handling
(2021-02-01)Cardiac function is defined by the process of excitation and contraction. During this process, the electrical excitation of the surface membrane is coupled to Ca2+-ion release at the sarcoplasmic reticulum, resulting in ... -
Role of MICOS for mitochondrial morphology and function
(2019-12-17)Mitochondria are highly dynamic organelles with a distinct morphological membrane ultrastructure. The mayor protein complex responsible for the formation and maintenance of the inner mitochondrial membrane is the ... -
Studying the role of coenzyme Q10 in mitochondrial calcium and redox signaling
(2022-06-30)Mitochondria can take up large amounts of calcium (Ca2+) in order to control the activity of several enzymes and their bioenergetics output. As a consequence of this metabolic flux, reactive oxygen species (ROS) are generated ...