Dokumente Molekulare Medizin nach Gutachter "Stadelmann-Nessler, Christine Prof. Dr."
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Alpha-synuclein-associated alterations at the synapse in models of Parkinson’s disease
(2023-08-16)Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is characterized by the typical motor features, and also by a multiplicity of non-motor symptoms. The main pathological hallmarks of PD ... -
Characterization of myelin-specific autoantibodies in an EAE mouse model
(2023-10-02)Abstract Autoimmune diseases are caused by an attack of the immune system against own tissues, but the exact effector mechanisms may vary between individual diseases and are not yet fully understood. The autoimmune disease ... -
Cholesterol metabolism in mouse models of Multiple Sclerosis
(2020-12-07)The primary origin of brain cholesterol is de novo synthesis due to limited entry peripheral cholesterol across the blood-brain barrier (BBB). Most if not all brain cells contribute to central nervous system (CNS) cholesterol ... -
Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ...