Browsing Molekulare Medizin by Referee "Thumm, Michael Prof. Dr."
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Analysis of the organization and signaling capacity of the membrane IgE during its interaction with CD19 and CD23 in B lymphocytes
(2021-07-27)The predominant allergy type I (hypersensitivity reaction type I) poses an increasing health issue in industrialized countries over the last decades. A key mediator in the pathogenesis of hypersensitivity or allergic ... -
Dissecting molecular elements of mitophagy and the lysis of intravacuolar vesicles
(2015-10-26)Autophagy is an evolutionary conserved catabolic process essential for the recycling and removal of cytosolic components via the lysosome (vacuole). Macroautophagy is characterized by the formation of a double membrane-layered ... -
Identification and Characterization of autophagic and non-autophagic Interaction Partners of Atg18
(2021-06-03)The PROPPIN Atg18 belongs to the WD40 repeat containing family and folds into a typical seven-bladed beta-propeller. Conserved regions at blade 5 and 6 allow for binding to phosphatidylinositolphosphates and mediate the ...