Molekulare Medizin
Recent Submissions
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The Role of Polycomb Repressive Complexes 1 in Diffuse Large B-cell Lymphoma
(2025-10-24)Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell non-Hodgkin lymphoma, known for its molecular heterogeneity. It includes transcriptomic-based subtypes, i.e. germinal center B-cell-like (GCB) and ... -
Determination of CaMKII and PKA role in PLN R14del functional phenotype
(2025-10-16)Phospholamban (PLN) is a 52-amino acid tail-anchored transmembrane protein and an essential regulator in the cardiac excitation-contraction coupling (ECC) involved in the regulation of the Sarcoendoplasmatic Reticulum ... -
Impact of Nucleosome Positioning in Promoters on Transcription Regulation for Selection of Expression Activating Transcription Factor Binding Sites
(2025-10-16)Gene regulation processes are crucial for development and the adaptation of cells, tissues or whole organisms to changing environments. Nucleosome positioning in promoter regions is of pivotal importance in gene regulation, ... -
Amyloid-β and phospho-Tau biomarkers immunoassay development and optimization to support the blood-based early and differential diagnosis of Alzheimer’s disease
(2025-10-13)The recent emergence of anti-amyloid treatments for early symptomatic Alzheimer’s disease (AD) require biomarker confirmation of amyloid pathology, increasing the need for biomarker testing. In the last few years, there ... -
Establishing a human microglia model to evaluate novel therapies for multiple sclerosis progression
(2025-09-22)Despite significant advances in the development of therapies for multiple sclerosis (MS), treating disease progression remains a major clinical challenge. MS progression refers to the accumulation of neurological disability ... -
Unraveling the Intercellular Interactions driven by Wnt-ß-catenin pathway in cardiac remodeling
(2025-08-29)Heart failure (HF) is the most common cardiovascular disease (CVD) and, despite significant pharmacological progress, it remains the leading cause of morbidity and mortality globally. One of the hallmarks of HF progression ... -
Super-Resolution Imaging Approaches To Determine The Organization of B Lymphocyte Surface Receptors
(2025-08-21)This thesis presents a multidisciplinary investigation into B cell membrane biology andnanobody-based molecular targeting, spanning the development of new imaging techniques,a novel nanobody discovery platform, and functional ... -
Immunocompetent Full-Skin Test System with Primary Immune Cells for Functional and Predictive Characterization of Contact Allergens
(2025-08-18)The skin is a complex organ composed of many different cell types that interact with each other, including various types of immune cells. Contact dermatitis is the most common skin disease and can be divided into irritative ... -
In vivo modelling of human central nervous system disease using chimeric mice
(2025-08-05)X-linked adrenoleukodystrophy (X-ALD) is a monogenic peroxisomal disorder caused by loss of function mutations in the ABCD1 gene, leading to impaired β-oxidation of very long-chain fatty acids (VLCFAs) and their pathological ... -
Interactome and Subcellular Analysis of the Tethering Proteins VAPA and VAPB in Cardiomyocytes
(2025-07-18)Heart muscle contraction is regulated by excitation-contraction-coupling (ECC), where calcium (Ca2+) released from the sarcoendoplasmic reticulum (SER) triggers myofilament contraction. The SER is crucial for intracellular ... -
Characterizing inflammatory transcription hubs in ARID1A-deficient PDAC subtypes
(2025-07-17)The SWitch/Sucrose Non-Fermentable (SWI/SNF) complex functions as a tumor suppressor in several tumor entities, including pancreatic ductal adenocarcinoma (PDAC). The AT-rich interaction domain-containing protein 1A (ARID1A) ... -
Single nucleus sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis
(2025-07-17)Cardiac fibrosis remains an unsolved clinical challenge, significantly contributing to mortality in chronic heart disease patients, with no specific antifibrotic therapy currently available. In our study, we performed ... -
Functional characterization of solute carriers with emphasis on proton-coupled organic cation antiporters
(2025-07-04)Solute carriers (SLCs) play an important role in the uptake of natural compounds and medically relevant drugs into various tissues, including the blood-brain barrier (BBB). Many cationic drugs rely on carrier-mediated ... -
NFATc1 and CRAC channel signaling in acute pancreatitis
(2025-07-04)Abstract Acute pancreatitis (AP) is an inflammatory disorder of the pancreas which is associated with an overall mortality of up to 5%. As its prevalence rises, the burden on the healthcare system and patients becomes ... -
Perturb-seq identified novel target genes and molecular pathways regulating cardiac fibrosis
(2025-06-12)Cardiac fibrosis is a prevalent feature in all forms of chronic heart disease, for which no definitive remedy exists to date. A hallmark of fibrosis is the transition of fibroblasts into their activated form, known as ... -
Elucidating the Molecular Pathologies in Mouse Models for Mitochondrial Diseases
(2025-06-04)The field of exploring mitochondrial diseases has gained much attention and notoriety in recent years. Individual mutations in proteins involved in mitochondrial structure and function are rare. However, when taken as a ... -
Impact of the Polymerization Method on the Biocompatibility of Denture Base Resins in a 3D Tissue Engineered Human Oral Mucosa Model
(2025-04-22)Poly(methyl methacrylate) (PMMA) is widely used in dentistry to fabricate removable dentures. As these materials come into direct contact with the oral mucosa, biocompatibility is essential to prevent adverse reactions ... -
The Role of Clonal Evolution and Anti- Apoptotic Dependencies in Cancer Progression and Therapy Resistance: Implications for Personalized Medicine
(2025-04-10)Cancer is characterized by significant heterogeneity, both across and within individual tumors, posing challenges for treatment. This thesis investigates clonal evolution (CE) and its association with apoptotic mechanisms ... -
The Functional Role of the Membrane Bending Ability of the Yeast PROPPINs
(2025-04-04)The meticulously regulated mechanism, which overseas processes of cellular breakdown and recycling, is called macroautophagy. It has been preserved from yeast to more advanced eukaryotic organisms. As a response to various ... -
Antibody-mediated recognition of central nervous system antigen as therapeutic target
(2025-04-04)The discovery of autoantibodies directed against myelin oligodendrocyte glycoprotein (MOG) in a proportion of patients diagnosed with multiple sclerosis (MS) led to the definition of MOG antibody-associated disease (MOGAD) ...