Molekulare Medizin
Recent Submissions
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Dissecting the Atg21 organization at the growing phagophore and the evolutionary conservation of Nvj1 among yeasts
(2024-12-09)The first project of this thesis deals with the spatial and temporal regulation of Atg21 at growing phagophores. Macroautophagy is a highly conserved process involved in the degradation and recycling of cellular material ... -
Role of the cellular prion protein in the cellular internalization and the Tau-mediated toxicity
(2024-11-15)Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of Tau within the brain, leading to neuronal dysfunction and death. These diseases are classified into 3R tauopathies, 4R ... -
Obesity and Ageing: accelerators of cognitive decline in melanocortin 4 receptor-deficient mice
(2024-10-14)Genetic or lifestyle-related obesity ails almost one billion people worldwide. Obesity is an accumulation of fat, while, ageing is an ongoing process of accumulation of harmful molecular alterations. Obesity and ageing, ... -
Regulation of the MDM4 oncogene by the ribosomal protein L22 through alternative mRNA splicing
(2024-09-27)p53 is the most frequently mutated tumor suppressor in human cancer. By acting as a transcription factor for its target genes, it causes downstream effects such as cell cycle arrest or apoptosis. To avoid excessive p53 ... -
Subcellular compartmentalization of signal elements and their re-distribution in resting and activated B cells
(2024-09-19)BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process ... -
Exploring new treatment strategies for mature T-cell neoplasms based on genetic alterations
(2024-09-10)Mature T-cell leukemias and lymphomas (mTCL) comprise a heterogeneous group of lymphoid malignancies that are generally associated with poor prognosis, low response to current standard therapy regimes and high relapse ... -
Pre-clinical assessment of the therapeutic efficacy of a nanovaccine in a mouse model of pancreatic cancer
(2024-08-09)Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases with increasing incidence in developed countries. Due to the late diagnosis of PDAC, available treatments do not significantly improve patient survival. ... -
Misp53 mutation-specific oncogenic transcription factor complexes in PDAC progression
(2024-07-02)Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second-leading cause of cancer related death by 2040 with a 5-year survival rate of only 11%. PDAC aggressiveness is attributed to its high heterogeneity ... -
3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
Functional and structural analysis approaches for translational lung disease research.
(2024-06-13)Respiratory ailments continue to pose a formidable challenge to public health. The respiratory system is a delicate interplay of muscle contraction, pressure gradients and a large surface area with thin diffusion barriers ... -
Characterizing immunomodulatory properties of a novel therapeutic approach for multiple sclerosis - Inhibition of Bruton's tyrosine kinase
(2024-05-06)Multiple Sclerosis is a complex and challenging chronic disease of the central nervous system (CNS), characterized by inflammation, demyelination, and neurodegeneration. The depletion of B cells using anti-CD20 antibodies ... -
Fibroblasts in colorectal cancer: Subtype diversity and immune cell modulation
(2024-02-20)Despite significant advances in early detection and treatment, colorectal cancer (CRC) remains one of the deadliest cancers worldwide. In case of advanced disease, immunotherapies, such as immune checkpoint inhibitors ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
Cellular prion protein in Alzheimer’s disease: Molecular insights and behavior implications
(2024-01-11)Alzheimer’s disease (AD) poses a substantial and increasing challenge, particularly due to our aging population, and its underlaying pathophysiology remains a topic of ongoing debate. Cellular prion protein (PrPC) has ... -
Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
Analysis of JCPy virus spread in human CNS tissue and establishment of PML models
(2023-12-07)Progressive multifocal leukoencephalopathy (PML) is a demyelinating CNS disease caused by the reactivation of the JC polyomavirus (JCPyV) in immunosuppressed individuals. The disease course is typically severe and in up ... -
Dynamics of the microbiome in pancreatic cancer from inception to invasion
(2023-10-23)Recently, the microbiome was associated with hallmark features of pancreatic ductal adenocarcinoma (PDAC). This dismal human disease with one of the lowest survival rates of below 10% is characterized by clinical challenges ... -
Defining the Role of Chromatin Remodeling Complexes in Control of Master Transcription Factor Networks in Pancreatic Cancer Subtype Switch
(2023-10-19)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease characterized by a dismal prognosis of 11%, projected to be the second-leading cause of cancer-related death by 2040. This urgent clinical challenge ... -
Spatial Architecture and Functional Characterization of Super Enhancer Associated Transcriptional Circuits in Aggressive Lymphomas
(2023-10-19)Aggressive lymphomas are clinically and biologically heterogenous entities, reflecting a diverse cell of-origins with multiple means of malignant transformation. With chemoimmunotherapy, a majority of patients suffering ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ...