Molekulare Medizin
Recent Submissions
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Characterizing inflammatory transcription hubs in ARID1A-deficient PDAC subtypes
(2025-07-17)The SWitch/Sucrose Non-Fermentable (SWI/SNF) complex functions as a tumor suppressor in several tumor entities, including pancreatic ductal adenocarcinoma (PDAC). The AT-rich interaction domain-containing protein 1A (ARID1A) ... -
Single nucleus sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis
(2025-07-17)Cardiac fibrosis remains an unsolved clinical challenge, significantly contributing to mortality in chronic heart disease patients, with no specific antifibrotic therapy currently available. In our study, we performed ... -
Functional characterization of solute carriers with emphasis on proton-coupled organic cation antiporters
(2025-07-04)Solute carriers (SLCs) play an important role in the uptake of natural compounds and medically relevant drugs into various tissues, including the blood-brain barrier (BBB). Many cationic drugs rely on carrier-mediated ... -
NFATc1 and CRAC channel signaling in acute pancreatitis
(2025-07-04)Abstract Acute pancreatitis (AP) is an inflammatory disorder of the pancreas which is associated with an overall mortality of up to 5%. As its prevalence rises, the burden on the healthcare system and patients becomes ... -
Perturb-seq identified novel target genes and molecular pathways regulating cardiac fibrosis
(2025-06-12)Cardiac fibrosis is a prevalent feature in all forms of chronic heart disease, for which no definitive remedy exists to date. A hallmark of fibrosis is the transition of fibroblasts into their activated form, known as ... -
Elucidating the Molecular Pathologies in Mouse Models for Mitochondrial Diseases
(2025-06-04)The field of exploring mitochondrial diseases has gained much attention and notoriety in recent years. Individual mutations in proteins involved in mitochondrial structure and function are rare. However, when taken as a ... -
Impact of the Polymerization Method on the Biocompatibility of Denture Base Resins in a 3D Tissue Engineered Human Oral Mucosa Model
(2025-04-22)Poly(methyl methacrylate) (PMMA) is widely used in dentistry to fabricate removable dentures. As these materials come into direct contact with the oral mucosa, biocompatibility is essential to prevent adverse reactions ... -
The Role of Clonal Evolution and Anti- Apoptotic Dependencies in Cancer Progression and Therapy Resistance: Implications for Personalized Medicine
(2025-04-10)Cancer is characterized by significant heterogeneity, both across and within individual tumors, posing challenges for treatment. This thesis investigates clonal evolution (CE) and its association with apoptotic mechanisms ... -
The Functional Role of the Membrane Bending Ability of the Yeast PROPPINs
(2025-04-04)The meticulously regulated mechanism, which overseas processes of cellular breakdown and recycling, is called macroautophagy. It has been preserved from yeast to more advanced eukaryotic organisms. As a response to various ... -
Antibody-mediated recognition of central nervous system antigen as therapeutic target
(2025-04-04)The discovery of autoantibodies directed against myelin oligodendrocyte glycoprotein (MOG) in a proportion of patients diagnosed with multiple sclerosis (MS) led to the definition of MOG antibody-associated disease (MOGAD) ... -
Mechanisms of T-cell mediated inflammatory neurodegeneration
(2025-04-04)Multiple sclerosis (MS) is a T-cell mediated, chronic, demyelinating disease of the central nervous system (CNS). Neurodegeneration and axonal loss are associated with increased disability and disease progression. ... -
Evaluation and Targeting of the Metabolic Signature of Human Pancreatic Ductal Adenocarcinoma Subtypes
(2025-03-13)Pancreatic ductal adenocarcinoma (PDAC) presents significant therapeutic challenges due to its pronounced tumor heterogeneity and complex metabolic reprogramming within the tumor microenvironment. In this study, advanced ... -
T cell-mediated ocular autoimmunity
(2025-03-07)Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system (CNS), leading to inflammatory lesions in the brain and spinal cord. The autoimmune process can affect both the gray and ... -
Understanding Early Events of B Cell Antigen Receptor Activation: Effects of Antigen and Receptor Valency
(2025-03-07)Abstract Each B cell is equipped with B cell antigen receptors (BCRs) of a unique specificity. These BCRs are crucial in many events including B cell development, activation and differentiation. There is still an ongoing ... -
Characterisation of colorectal cancer by means of imaging to allocate patients to best treatment options
(2025-01-23)Colorectal cancer (CRC) is currently the second deadliest cancer in the world. Apart from the known prognostic factors, the role of tumour microenvironment (TME), in particular the extracellular matrix (ECM) has gained ... -
Long-term Replacement of Endogenous Microglia in Mice
(2024-12-19)Microglia are the resident immune cells of the central nervous system (CNS). They play pivotal roles in the development and homeostasis of the CNS and have been implicated in neurodegenerative disorders, such as Alzheimer´s ... -
Dissecting the Atg21 organization at the growing phagophore and the evolutionary conservation of Nvj1 among yeasts
(2024-12-09)The first project of this thesis deals with the spatial and temporal regulation of Atg21 at growing phagophores. Macroautophagy is a highly conserved process involved in the degradation and recycling of cellular material ... -
Role of the cellular prion protein in the cellular internalization and the Tau-mediated toxicity
(2024-11-15)Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of Tau within the brain, leading to neuronal dysfunction and death. These diseases are classified into 3R tauopathies, 4R ... -
Obesity and Ageing: accelerators of cognitive decline in melanocortin 4 receptor-deficient mice
(2024-10-14)Genetic or lifestyle-related obesity ails almost one billion people worldwide. Obesity is an accumulation of fat, while, ageing is an ongoing process of accumulation of harmful molecular alterations. Obesity and ageing, ... -
Regulation of the MDM4 oncogene by the ribosomal protein L22 through alternative mRNA splicing
(2024-09-27)p53 is the most frequently mutated tumor suppressor in human cancer. By acting as a transcription factor for its target genes, it causes downstream effects such as cell cycle arrest or apoptosis. To avoid excessive p53 ...