Molekulare Medizin
Recent Submissions
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Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
High throughput strategies for electrophysiological characterisation of cardiomyocytes
(2023-08-22)Personalised medicine describes the customised application of medical treatment at a patient-specific level. This type of precision medicine stratifies patients based on their specific genotype or phenotype for targeted ... -
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Alpha-synuclein-associated alterations at the synapse in models of Parkinson’s disease
(2023-08-16)Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is characterized by the typical motor features, and also by a multiplicity of non-motor symptoms. The main pathological hallmarks of PD ... -
Modulation of HSF1 activity by p53 and its impact in cancer therapies
(2023-07-13)The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ... -
Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
The Role of Heat Shock Protein A4 (HSPA4) in the Heart
(2023-07-07)Non-ischemic cardiomyopathies may be caused by genetic mutations but may also result from cytotoxic influences of chemotherapeutic drugs and the accumulation of misfolded proteins. Heat shock protein A4 (HSPA4) ... -
TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
Atrial mitochondrial calcium handling in patients with atrial fibrillation
(2023-05-30)Atrial fibrillation (AF) is the most common form of arrhythmia however, due to the incomplete understanding of its molecular mechanisms, there are several limitations of the currently available therapeutic strategies. ... -
Effects of acute and long-term tachypacing on atrial engineered human myocardium
(2023-04-27)Atrial fibrillation is the most common supraventricular arrhythmia and is associated with molecular remodelling that promotes the maintenance and worsening of the disease. Although extensive research has been performed to ... -
Effects of histone 3.3K27M-mutation on CREB binding protein (CBP/p300)- and bromodomain and extra terminal domain (BET) protein- mediated gene regulation in diffuse intrinsic pontine gliomas (DIPG)
(2023-04-25)Diffuse intrinsic pontine gliomas (DIPG) are incurable pediatric high-grade tumors. The majority of all DIPG carries a mutation in one of the histone 3 genes leading to a substitution of lysine 27 to methionine (H3 K27M) ... -
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
(2023-03-09)Microvascular dysfunction is a pathological hallmark of the diabetic myocardium, and is central to the etiology of diabetes-associated cardiac events. Herein, previous studies highlighted the role of the vasoactive micro-RNA ... -
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
(2023-02-23)MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ... -
BAX and BAK - the deadly rings. A comprehensive study of the mitochondrial apoptotic pore in situ with super-resolution microscopy
(2023-02-23)Apoptosis, the most common form of cell death in the human body, is essential for numerous physiological processes. The intrinsic apoptosis pathway can be triggered by a wide variety of stimuli and leads to the insertion ... -
Mild production of reactive oxygen species reversibly affects the metabolism and function of the heart
(2023-01-25)Reactive oxygen species (ROS) are molecular oxygen derivatives that are produced as an attribute of aerobic life. The relationship between elevated levels of ROS and heart failure (HF) has been extensively studied. However, ... -
Differentiation-Induced Rearrangement of the Mitochondrial Calcium Uniporter Complex Regulates T-Cell-Mediated Immunity
(2023-01-20)CD4+ T-cells are an important cell type involved in proper mediation of the human adaptive immune system. Activation of CD4+ T-cells is a regulated process which includes a tightly controlled cytosolic calcium (Ca2+) ... -
Optimization of the RT-QuIC in prion disease diagnostic
(2023-01-11)In the present work, we were interested in applying different recombinant prion proteins (rec PrP) as substrates in the real-time quaking-induced conversion (RT-QuIC) assay to improve the diagnostic accuracy in different ... -
Novel therapeutic approaches to treat inflammatory conditions with glucocorticoid and calciferol nanoparticles in vivo and in vitro
(2023-01-10)The body is constantly confronted with environmental threats and sometimes the entry of pathogens leads to severe inflammatory conditions such as sepsis or acute lung injury (ALI). Both diseases are characterized by a ... -
The role of the receptor tyrosine kinase-like orphan receptors (RORs) in human breast cancer
(2022-12-05)Breast and colorectal cancers are among the most common tumor types worldwide and the occurrence of metastases is often associated with a shortened lifespan. One of the signaling pathways that has been frequently ...