Cardiac functions of the cellular oxygen sensors prolyl-4-hydroxylase domain enzymes 2 and 3

Hölscher, Marion

dc.contributor.advisor	Katschinski, Dörthe Prof. Dr.	de
dc.contributor.author	Hölscher, Marion	de
dc.date.accessioned	2013-01-14T15:06:07Z	de
dc.date.available	2013-01-30T23:50:52Z	de
dc.date.issued	2012-07-24	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-EF6B-F	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-1434
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Cardiac functions of the cellular oxygen sensors prolyl-4-hydroxylase domain enzymes 2 and 3	de
dc.type	doctoralThesis	de
dc.title.translated	Kardiale Funktionen der zellulären Sauerstoffsensoren Proly-4-Hydroxylase-Domäne Enzyme 2 und 3	de
dc.contributor.referee	Pöggeler, Stefanie Prof. Dr.	de
dc.date.examination	2012-06-06	de
dc.subject.dnb	570 Biowissenschaften, Biologie	de
dc.subject.gok	WA 000	de
dc.description.abstracteng	Cardiovascular diseases are the major cause of death in the western world and produce furthermore the highest medical costs among all diseases. About 41% of all deaths in Germany in the year 2010 can be attributed to cardiovascular diseases. About 17% of these deaths were caused by myocardial infarction. Cardiac tissue protection in case of acute ischemia could therefore result in better short and long term survival of these patients. In 2003 it was described for the first time that the Hypoxia-inducible factor (HIF), a heterodimeric transcription factor, which is stabilized under hypoxic conditions, e.g. in myocardial infarction, can mediate cardioprotection. It was shown that the cardioprotective effect of intermittent hypoxia is dependent on the HIF-1α gene dosage. This was shown by a better ventricular contractile function and a significantly smaller infarct size following ischemia-reperfusion in mice pretreated with intermittent hypoxia. Since then a lot of subsequent papers have been published that demonstrate the crucial role for HIF-1 in various modalities of cardioprotection. With the discovery of the HIF regulating proly-4 hydroxylase domain (PHD) enzymes 1-3 potential therapeutic targets to modulate HIF-1α stability and thus possibilities to improve ischemic diseases have been discovered. Despite these findings a lot of open questions remain that will be addressed in my PhD thesis.	de
dc.contributor.coReferee	Alves, Frauke Prof. Dr.	de
dc.contributor.thirdReferee	Katschinski, Dörthe Prof. Dr.	de
dc.subject.topic	Biology (incl. Psychology)	de
dc.subject.ger	PHD2	de
dc.subject.ger	PHD3	de
dc.subject.ger	HIF	de
dc.subject.eng	PHD2	de
dc.subject.eng	PHD3	de
dc.subject.eng	HIF	de
dc.subject.bk	44.37	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-3628-8	de
dc.identifier.purl	webdoc-3628	de
dc.affiliation.institute	Biologische Fakultät	de
dc.identifier.ppn	731592166	de

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Fakultät für Biologie und Psychologie (inkl. GAUSS) [1621]

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