The NF-κB signaling pathway in melanoma cells and implications for its therapeutic modulation
Der NF-κB Signalweg in Melanomzellen und Implikation für seine therapeutische Modulation
von Nadin Pletz
Datum der mündl. Prüfung:2012-09-24
Erschienen:2012-12-10
Betreuer:Prof. Dr. Michael P. Schön
Gutachter:Prof. Dr. Michael P. Schön
Gutachter:Prof. Dr. Matthias Dobbelstein
Gutachter:Prof. Dr. Jürgen Wienands
Dateien
Name:pletz.pdf
Size:3.03Mb
Format:PDF
Zusammenfassung
Englisch
One of the major challenges in cancer therapy is to overcome drug resistance. Melanoma cells are an illustrative example for this notion, as metastasized melanoma is almost universally resistant against chemotherapy. The NF-κB signaling pathway is constitutively active and plays a crucial role for drug resistance in melanoma cells. This work starts from the observation that doxorubicin leads to profound activation of NF-κB in two different melanoma cell lines, while several other chemotherapeutics with different modes of action did not activate this pathway. Likewise, NF-κB dependent transcription of mediators, which are thought to be involved in tumor progression, was increased by doxorubicin. Notably, the strongest NF-κB activation was detected at a concentration of 1
Keywords: melanoma; chemoresistance; NF-κB; ATM; IKKα; IKKβ; NF-κB inhibition
Schlagwörter: Melanom; Chemoresitenz; NF-κB; ATM; IKKα; IKKβ; NF-κB-Inhibition