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The NF-κB signaling pathway in melanoma cells and implications for its therapeutic modulation

dc.contributor.advisorSchön, Michael P. Prof. Dr.de
dc.contributor.authorPletz, Nadinde
dc.date.accessioned2013-01-14T15:07:47Zde
dc.date.available2013-01-30T23:51:03Zde
dc.date.issued2012-12-10de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-000D-EF8C-5de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-1487
dc.format.mimetypeapplication/pdfde
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de
dc.titleThe NF-κB signaling pathway in melanoma cells and implications for its therapeutic modulationde
dc.typedoctoralThesisde
dc.title.translatedDer NF-κB Signalweg in Melanomzellen und Implikation für seine therapeutische Modulationde
dc.contributor.refereeSchön, Michael P. Prof. Dr.de
dc.date.examination2012-09-24de
dc.subject.dnb570 Biowissenschaften, Biologiede
dc.subject.gokMolekularmedizinde
dc.description.abstractengOne of the major challenges in cancer therapy is to overcome drug resistance. Melanoma cells are an illustrative example for this notion, as metastasized melanoma is almost universally resistant against chemotherapy. The NF-κB signaling pathway is constitutively active and plays a crucial role for drug resistance in melanoma cells. This work starts from the observation that doxorubicin leads to profound activation of NF-κB in two different melanoma cell lines, while several other chemotherapeutics with different modes of action did not activate this pathway. Likewise, NF-κB dependent transcription of mediators, which are thought to be involved in tumor progression, was increased by doxorubicin. Notably, the strongest NF-κB activation was detected at a concentration of 1de
dc.contributor.coRefereeDobbelstein, Matthias Prof. Dr.de
dc.contributor.thirdRefereeWienands, Jürgen Prof. Dr.de
dc.subject.topicBiology (incl. Psychology)de
dc.subject.gerMelanomde
dc.subject.gerChemoresitenzde
dc.subject.gerNF-κBde
dc.subject.gerATMde
dc.subject.gerIKKαde
dc.subject.gerIKKβde
dc.subject.gerNF-κB-Inhibitionde
dc.subject.engmelanomade
dc.subject.engchemoresistancede
dc.subject.engNF-κBde
dc.subject.engATMde
dc.subject.engIKKαde
dc.subject.engIKKβde
dc.subject.engNF-κB inhibitionde
dc.subject.bk42.13de
dc.identifier.urnurn:nbn:de:gbv:7-webdoc-3834-2de
dc.identifier.purlwebdoc-3834de
dc.affiliation.instituteBiologische Fakultätde
dc.identifier.ppn73789783Xde


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