dc.contributor.advisor | Hoerauf, Hans Prof. Dr. | de |
dc.contributor.author | Schäfer, Kristine | de |
dc.date.accessioned | 2013-01-14T15:16:26Z | de |
dc.date.available | 2013-01-30T23:50:51Z | de |
dc.date.issued | 2012-04-18 | de |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-000D-EF9F-C | de |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-1505 | |
dc.description.abstract | Hintergrund: Die AMD ist die häufigste
Ursache für Erblindung und Verlust der Sehschärfe in der westlichen
Welt bei Patienten in einem Alter über 65 Jahre und die Inzidenz
wird auch in den kommenden Jahren auf Grund der immer älter
werdenden Bevölkerung weiter zunehmen. Derzeit ist die
intravitreale Injektion von VEGF-Inhibitoren das Mittel der Wahl in
der Therapie der exsudativen AMD, da es ein relativ risikoarmes
Verfahren mit verhältnismäßig großem therapeutischen Nutzen
darstellt. Allerdings handelt es sich in den meisten Fällen um eine
Dauertherapie, die mehrere Injektionen pro Jahr erforderlich
macht.
Das Ziel der Studie war, die kardiovaskulären Nebenwirkungen nach
der Upload-Phase von 3 Injektionen von Bevacizumab und Ranibizumab
zu erfassen.
Ergebnisse: In der vorliegenden Studie mit 111 Patienten der
Universitätsmedizin Göttingen konnte für die VEGF-Inhibitoren
Avastin | de |
dc.format.mimetype | application/pdf | de |
dc.language.iso | ger | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | de |
dc.title | Erhebung über mögliche kardiovaskuläre Nebenwirkungen nach intravitrealer Injektion der VEGF-Inhibitoren Bevacizumab und Ranibizumab bei altersbedingter Makuladegeneration | de |
dc.type | doctoralThesis | de |
dc.title.translated | Investigation about possible cardiovascular adverse events after intravitreal application of VEGF-inhibitors bevacizumab and ranibizumab in therapy of age-related maculopathy | de |
dc.contributor.referee | Hoerauf, Hans Prof. Dr. | de |
dc.date.examination | 2012-04-18 | de |
dc.subject.dnb | 610 Medizin, Gesundheit | de |
dc.subject.gok | MED 520 Ophthalmologie | de |
dc.description.abstracteng | Background: Age-related macular
degeneration is the most common cause of blindness in the western
civilisation in patients more than 65 years old. The incidence of
AMD will increase in the following years according to increased
life expectancy.
At this time intravitreous injection of VEGF inhibitors is the
first choice in treatment of exsudative amd because of being a
low-risk but highly efficiant drug. Nevertheless it is mostly
needed to be used continuously for several years. This study's
intention was to find out about cardiovascular side effects after 3
doses of intravitreal bevacizumab and ranibizumab.
Results: In this study with 111 patients of the university hospital
in Göttingen we did not find an elevated risk for cardiovascular
side effects after 3 months respectively 3 injections of
bevacizumab and ranibizumab. Very few cases of angina pectoris or
raising of blood pressure medication occurred of which correlation
to the VEGF inhibitors is not securely to be made with this small
amount of participants. Compared to incidences from cardiovascular
trials they rather seem to be due to normal age-dependent
distribution. Data show that even patients with history of
cardiovascular diseases did not suffer from events like heart
attack, apoplexy, arterial embolism, venous thrombosis or permanent
elevated blood pressure during treatment period. Also there was no
difference shown between bevacizumab und ranibizumab.
Conclusions: There has to be further evaluation of risk factors of
cardiovascular diseases in trials including a bigger number of
cases to find out how much they are concordant to the risk factors
of amd, what role anti-VEGF medication is really having in
pathogenesis of the above-mentioned diseases and if there are
long-term side effects. | de |
dc.contributor.coReferee | Schäfer Prof. Dr. | de |
dc.contributor.thirdReferee | Stojanovic, Tomislav PD Dr. | de |
dc.subject.topic | Medicine | de |
dc.subject.ger | AMD | de |
dc.subject.ger | VEGF-Inhibitoren | de |
dc.subject.ger | Kardiovaskuläre Nebenwirkungen | de |
dc.subject.eng | ARM | de |
dc.subject.eng | VEGF-Inhibitors | de |
dc.subject.eng | cardiovascular side effects | de |
dc.subject.bk | 44.95 Augenheilkunde | de |
dc.identifier.urn | urn:nbn:de:gbv:7-webdoc-3469-8 | de |
dc.identifier.purl | webdoc-3469 | de |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.identifier.ppn | 72019072X | de |