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Untersuchung zur Modulierbarkeit der sensorischen Schmerzwahrnehmung durch Theta-Burst-Stimulation

Theta burst stimulation of the motor cortex reduces laser-evoked pain perception

by Maik Levold
Doctoral thesis
Date of Examination:2012-04-17
Date of issue:2012-04-19
Advisor:Prof. Dr. Andrea Antal
Referee:Prof. Dr. Ekkehard Wilichowski
Referee:Prof. Dr. Rainer Mausberg
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-1507

 

 

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Abstract

English

Theta burst stimulation of the motor cortex reduces laser-evoked pain perception. Repetitive transcranial magnetic stimulation over the primary motor cortex (M1) was recently introduced to modulate pain perception. The aim of this double-blind cross-over study was to investigate the effect of a modified rTMS paradigm, called cTBS on experimentally induced laser-evoked pain applied over the left M1. cTBS inhibits the cortical excitability of the M1 for approximately 1 h. Subjective pain was measured using the verbal analogue scale prior to, immediately after and 30 min post-stimulation. cTBS, and not the sham stimulation resulted in a significant decrease in pain perception on both hands, accentuated on the right hand. Further studies are needed using motor cortex TBS in chronic pain to pave the way towards a therapeutic tool.
Keywords: cTBS; rTMS

Other Languages

Untersuchung zur Modulation der sensorischen Schmerzwahrnehmung durch Theta-Burst-Stimulation Die repetetive Transkranielle Magnet Stimulation des primären Motorkortex (M1) wurde kürzlich eingeführt, um Schmerzwahrnehmung zu modulieren. Das Ziel dieser Double-Blind-Cross Over Studie war es, die Wirkung einer modifizierten rTMS, genannt cTBS zu untersuchen. cTBS hemmt die kortikale Erregbarkeit für etwa 1 h. Subjektiver Schmerz wurde gemessen und verbal vom Patienten eingeschätzt; sofort nach cTBS Stimulation und 30 Minuten danach. Durch cTBS konnte eine signifikante Schmerzreduktion an beiden Händen erzeugt werden. Weitere Studien werden nötig sein, um diese Effekte bei z.B. chronischen Schmerzgeschehen zu untersuchen.
Schlagwörter: cTBS; rTMS
 

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