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Funktionelle und genetische Variabilität bei der zytotoxischen Wirkung von Nukleosid-Analoga

Functional and genetic variability in the cytotoxic action of nucleosid analogues

by Christian Kuschel
Doctoral thesis
Date of Examination:2012-05-16
Date of issue:2012-04-19
Advisor:Dr. Markus Schirmer
Referee:Prof. Dr. Jürgen Brockmöller
Referee:Prof. Dr. Gerald Wulf
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-1508

 

 

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Abstract

English

The objekt of this work was the detection of genetic polymorphisms which impact the efficacy of gemcitabine and cytarabine, two nucleoside analogues employed as cytostatic drugs in treatment of cancer. As investigational material of this study, isolated human leucocytes of 72 healthy donors and 54 lymphoblastoid cell lines were used and the variability of the cytotoxicity of these two drugs was measured. The projekt aims to contribute to the optimisation and individualisation of the chemotherapy with gemcitabine and cytarabine.
Keywords: Gemcitabine; cytarabine; ENT 1; lymphoblastoid cell lines; genetic polymorphisms; chemotherapy; nucleoside analogues

Other Languages

Gegenstand dieser Arbeit ist die Identifizierung genetischer Polymorphismen, welche die Wirksamkeit der als Zytostatika eingesetzten Nukleosid-Analoga Gemcitabin und Cytarabin beeinflussen. Als Untersuchungsmaterial dienten isolierte Leukozyten von 72 gesunden Spendern sowie 54 lymphoblastoide Zelllinien, an denen jeweils die Variabilität der Zytotoxizität dieser beiden Substanzen gemessen wurde. Das Ziel ist die Optimierung der Chemotherapie mit Gemcitabin und Cytarabin in der Behandlung von Krebserkrankungen.
Schlagwörter: Gemcitabin; Cytarabin; ENT 1; lymphoblastoide Zelllinen; genetische Polymorphismen; Chemotherapie; Nukleosid-Analoga
 

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