Inzidenz von Zweittumoren bei Patienten mit zuvor kurativ behandeltem Tumor im Hals-Nasen-Ohren-Bereich - eine prospektive Analyse

Wolff, Cornelia Ruth Marie

dc.contributor.advisor	Christiansen, Hans Prof. Dr.	de
dc.contributor.author	Wolff, Cornelia Ruth Marie	de
dc.date.accessioned	2013-01-14T15:17:47Z	de
dc.date.available	2013-01-30T23:50:51Z	de
dc.date.issued	2012-05-16	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-EFAF-8	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-1520
dc.description.abstract	Durch eine Vielzahl von Studien und Literaturnachweisen ist bekannt, dass Patienten mit den Risikofaktoren Nikotin- und Alkoholabusus ein deutlich erhöhtes Risiko aufweisen, an malignen Tumoren zu erkranken. Dies führt zu der Überlegung, bei diesen Patienten mittels Screeningverfahren die Früherkennung von Tumoren zu verbessern. Dies gilt insbesondere auch für Patienten, welche zuvor bereits kurativ aufgrund eines Tumors im HNO-Bereich behandelt worden sind, da die heutige multimodale Therapie immer bessere Überlebensraten ermöglicht und gerade diese Patienten häufig entsprechende Risikofaktoren aufweisen. Somit werden insbesondere bei diesen Patienten im weiteren Verlauf nach kurativer Behandlung des Kopf-Hals-Tumors zunehmend Zweittumore in der Lunge oder dem	de
dc.format.mimetype	application/pdf	de
dc.language.iso	ger	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Inzidenz von Zweittumoren bei Patienten mit zuvor kurativ behandeltem Tumor im Hals-Nasen-Ohren-Bereich - eine prospektive Analyse	de
dc.type	doctoralThesis	de
dc.title.translated	Incidence of secondary malignant tumors in patients with curatively treated head and neck cancer - a prospective analysis	de
dc.contributor.referee	Christiansen, Hans Prof. Dr.	de
dc.date.examination	2012-05-22	de
dc.subject.dnb	610 Medizin, Gesundheit	de
dc.subject.gok	MED 424	de
dc.description.abstracteng	Patients treated previously for a head and neck squamous cell carcinoma (HNSCC) carry a high-risk for second malignant tumors, particularly for other head and neck tumors, lung cancer and esophageal cancer. The main risk factors for the development of such malignancies are widespread agents like tobacco smoking often in combination with abuse of alcohol. Since the long-term outcome of patients with HNSCC has improved through optimized multimodal approaches including surgery, radio(chemo)therapy, or combination of both, the incidence of subsequent cancers has become a life-limiting factor. The present study evaluated the potential benefit of a CT of the chest, an endoscopy of the esophagus and stomach and an ear-nose-throat endoscopy for early detection of second malignant tumors for HNSCC patients at high-risk. Therefore, between 07/2008 and 11/2011 participants underwent a systematic examination for second malignant tumors. All patients had been treated for a HNSCC 1 to 140 months before examination and showed no loco-regional relapse or distant metastases, so far. Overall, 118 consecutive patients were recruited. In total 33 suspicious findings were clarified by additional investigations. By these procedures, 26 second malignant tumors were confirmed within 21 patients (10 lung, 7 head and neck, 3 gastrointestinal, 1 renal tumor(s)). Subsequently, 18 of these 21 patients (86%) could be treated again in curative intent. In summary we found a high prevalence of curable second malignant tumors in a defined subgroup of patients at high-risk with prior HNSCC. All tumors were asymptomatic at the point of examination and were mostly detected in an early tumor stage, which may lead to a lower rate of tumor dependent mortality. To proof a lower rate of mortality prospective multicenter long-term studies are necessary.	de
dc.contributor.coReferee	Hommerich, Christian Prof. Dr.	de
dc.subject.topic	Medicine	de
dc.subject.ger	HNO-Tumor	de
dc.subject.ger	Risikofaktoren	de
dc.subject.ger	Nikotin	de
dc.subject.ger	Alkohol	de
dc.subject.ger	Zweittumor	de
dc.subject.ger	Bronchialkarzinom	de
dc.subject.ger	Oesophaguskarzinom	de
dc.subject.ger	CT-Thorax	de
dc.subject.ger	Gastroskopie	de
dc.subject.ger	Screening	de
dc.subject.ger	Früherkennung	de
dc.subject.eng	head and neck cancer	de
dc.subject.eng	HNSCC	de
dc.subject.eng	risk factor	de
dc.subject.eng	nicotine	de
dc.subject.eng	alcohol	de
dc.subject.eng	second tumor	de
dc.subject.eng	lung cancer	de
dc.subject.eng	esophageal cancer	de
dc.subject.eng	CT-Thorax	de
dc.subject.eng	gastroscopy	de
dc.subject.eng	screening	de
dc.subject.eng	early diagnosis	de
dc.subject.bk	44.64	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-3506-0	de
dc.identifier.purl	webdoc-3506	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.identifier.ppn	72053559X	de

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Human- und Zahnmedizin [2872]

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