Navigation ▼

Show simple item record

dc.contributor.advisor Stadelmann-Nessler, Christine Prof. Dr. de
dc.contributor.author Schultz, Katharina de
dc.date.accessioned 2013-01-14T15:19:05Z de
dc.date.available 2013-01-30T23:51:27Z de
dc.date.issued 2012-05-31 de
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-000D-EFBE-6 de
dc.format.mimetype application/pdf de
dc.language.iso ger de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ de
dc.title De - und Remyelinisierung in Dopaminrezeptor-defizienten Mäusen de
dc.type doctoralThesis de
dc.title.translated De-and remyelination in dopamine receptor-deficient mice de
dc.contributor.referee Stadelmann-Nessler, Christine Prof. Dr. de
dc.date.examination 2012-06-27 de
dc.subject.dnb 610 Medizin, Gesundheit de
dc.subject.gok MED 531 de
dc.description.abstracteng De-and remyelination in dopamine receptor-deficient mice Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous-system with destruction of myelin sheaths, axonal damage and only partial remyelination. In non remyelinated MS lesions there is often a significant loss of oligodendrocytes. The destruction of oligodendrocytes happens predominantly at the beginning a lesion occurs. In this work the effect of the dopamine D2 receptor (DRD2) and D3 (DRD3) and dopamine agonist pramipexole relating to the oligodendroglial survival in the model of cuprizone-induced demyelination has been tested for toxicity. The literature has shown the expression of DRD2 and DRD3 on oligodendrocyte percusor cells (OPCs) and an effect on the extent of concentration of oligodendrocytes. Our hypothesis is that dopamine receptor-deficient mice compared to wild type (wt) mice have shown an increased vulnerability of oligodendrocytes. Furthermore, it should be investigated how far the therapy with pramipexole, a dopamine D3 receptor agonist, receptor-independent or dependent, leads to a protection of oligodendrocytes. With the help of various histological and immunohistochemical methods we were allowed to count the density of apoptotic oligodendrocytes and activated microglia, which drew conclusions from the extent of tissue damage. We could not find significant differences in the density of apoptotic oligodendrocytes and activated microglia between the different experimental groups. In one experiment, more apoptotic oligodendrocytes were found in the animals of the wild-type PBS (phosphate buffered saline) group compared with the pramipexole-treated DRD3 knockout mice, which may allow to draw conclusions from receptor-independent effects of pramipexole. These results must be reproduced in further studies in detail and will have to be verified. So it appears that endogenous dopamine receptor system plays no significant role in our results - the protection of oligodendrocytes in cuprizone-induced damage. Furthermore, a preventive-protective effect of pramipexole can de
dc.contributor.coReferee Simons, Mikael Prof. Dr. de
dc.contributor.thirdReferee Liebetanz, David Prof. Dr. de
dc.subject.topic Medicine de
dc.subject.ger Multiple Sklerose - Neuropathologie - Dopaminrezeptordefizienz - Pramipexol - Oligodendrocytenvorläuferzellen OPCs de
dc.subject.eng muliple sclerosis - neuropathology - dopamine receptor deficiency - pramipexole - oligodendrocyte percusor cells OPCs de
dc.subject.bk 44.90 de
dc.identifier.urn urn:nbn:de:gbv:7-webdoc-3533-0 de
dc.identifier.purl webdoc-3533 de
dc.affiliation.institute Medizinische Fakultät de
dc.identifier.ppn 726808385 de

Files in this item

This item appears in the following Collection(s)

Show simple item record