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Epigenetische Kontrolle der Remyelinisierung bei Multipler Sklerose

Epigenetic control of remyelinisation in multiple sclerosis

Anna Theresia Herget
Doctoral thesis
Date of Examination: 2012-06-27
Date of issue: 2012-06-15
Advisor: Stadelmann-Nessler, Christine Prof. Dr.
Referee: Stadelmann-Nessler, Christine Prof. Dr.
Referee: Reuss, Bernhard Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-000D-EFCD-6

 

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Abstract

English

A great variability of remyelinisation is frequently found in demyelinated plaques of patients with multiple sclerosis (MS). Regarding this variability recent studies have found a correlation between the Histone deacetylase 1 (HDAC1)-expression and the level of remyelinisation in mice. In this study we concentrated on the question whether this coherence also could be seen in patients with MS. Beforehand, we developed a classification for stages of remyelinating lesions by means of differential expression of various myelin proteins in oligodendrocytes. It showed that 2
Keywords: multiple sclerosis; HDAC1; remyelinisation; stages of remyelinisation; NogoA; CNP; MOG; MAG; MBP
Schlagwörter: Multiple Sklerose; HDAC1; Remyelinisierung; Remyelinisierungsstadien; NogoA; CNP; MOG; MAG; MBP
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