Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin
Funktionale und Mutationale Analyse von der Kinase Domäne des Gigantischen Protein Titin
by Aleksandra Kirova
Date of Examination:2012-06-26
Date of issue:2012-06-20
Advisor:Prof. Dr. Ralph Knöll
Referee:Prof. Dr. Susanne Lutz
Referee:Prof. Dr. Peter Schu
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Abstract
English
The giant filamentous muscle protein titin spans half of the sarcomere. Through its tight association with the thick filament, its elastic elements at the I-band, its connection to the cytoskeleton components, and its anchorage at the Z-disc and M-line, the protein is proposed to participate in the mechanosensation and -transduction, to provide mechanical stability to the sarcomere as well as to possibly serve as a “molecular ruler,
Keywords: titin; dilated cardiomyopathy; mechanotransduction; yeast two hybrid
Schlagwörter: titin; dilatative Kardiomyopathie; mechanotransduktion; Hefe-Dihybrid