Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin

Funktionale und Mutationale Analyse von der Kinase Domäne des Gigantischen Protein Titin

by Aleksandra Kirova
Doctoral thesis
Date of Examination:2012-06-26
Date of issue:2012-06-20
Advisor:Prof. Dr. Ralph Knöll
Referee:Prof. Dr. Susanne Lutz
Referee:Prof. Dr. Peter Schu
Persistent Address: http://dx.doi.org/10.53846/goediss-1555

 

 

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Abstract

English

The giant filamentous muscle protein titin spans half of the sarcomere. Through its tight association with the thick filament, its elastic elements at the I-band, its connection to the cytoskeleton components, and its anchorage at the Z-disc and M-line, the protein is proposed to participate in the mechanosensation and -transduction, to provide mechanical stability to the sarcomere as well as to possibly serve as a “molecular ruler,
Keywords: titin; dilated cardiomyopathy; mechanotransduction; yeast two hybrid
Schlagwörter: titin; dilatative Kardiomyopathie; mechanotransduktion; Hefe-Dihybrid
 
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