Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin

Funktionale und Mutationale Analyse von der Kinase Domäne des Gigantischen Protein Titin

von Aleksandra Kirova
Dissertation
Datum der mündl. Prüfung:2012-06-26
Erschienen:2012-06-20
Betreuer:Prof. Dr. Ralph Knöll
Gutachter:Prof. Dr. Susanne Lutz
Gutachter:Prof. Dr. Peter Schu
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-1555

 

 

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Zusammenfassung

Englisch

The giant filamentous muscle protein titin spans half of the sarcomere. Through its tight association with the thick filament, its elastic elements at the I-band, its connection to the cytoskeleton components, and its anchorage at the Z-disc and M-line, the protein is proposed to participate in the mechanosensation and -transduction, to provide mechanical stability to the sarcomere as well as to possibly serve as a “molecular ruler,
Keywords: titin; dilated cardiomyopathy; mechanotransduction; yeast two hybrid
Schlagwörter: titin; dilatative Kardiomyopathie; mechanotransduktion; Hefe-Dihybrid
 
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