Differenzielle Beeinflussung endothelialer Antigene und dynamischer Endothel-Lymphozyten-Interaktionen durch Dimethylfumarat und Monomethylfumarat

Drick, Nora

dc.contributor.advisor	Schön, Michael P. Prof. Dr.	de
dc.contributor.author	Drick, Nora	de
dc.date.accessioned	2013-01-14T15:27:24Z	de
dc.date.available	2013-11-30T23:50:05Z
dc.date.issued	2012-07-11	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-EFDF-D	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-1568
dc.format.mimetype	application/pdf	de
dc.language.iso	ger	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Differenzielle Beeinflussung endothelialer Antigene und dynamischer Endothel-Lymphozyten-Interaktionen durch Dimethylfumarat und Monomethylfumarat	de
dc.type	doctoralThesis	de
dc.title.translated	The influence of dimethylfumarate and monomethylfumarate on endothelial antigen expression and dynamic lymphocyte-endothelial cell interactions	de
dc.contributor.referee	Schäfer, Katrin Prof. Dr.	de
dc.date.examination	2012-07-18	de
dc.subject.dnb	610 Medizin, Gesundheit	de
dc.subject.gok	MED 481	de
dc.description.abstracteng	For years Fumaric acid esters (FAE) have been successfully used in the systemic treatment of severe psoriasis. However, their pleiotropic mode of action is not yet fully understood. To further elucidate the mode of action of FAE, the effect of dimethylfumarate (DMF) and monomethylfumarate (MMF) on human endothelial cells in vitro was investigated. As Psoriasis is associated with inflammatory lymphocytic infiltrates, it was focused on adhesion molecule expression and the interaction between endothelial cells and human peripheral blood mononuclear cells (PBMC) under conditions of shear flow. Dimethylfumarate concentration-dependently reduced the TNFα-induced expression of E-selectin (CD62E), ICAM-1 (CD54) and VCAM-1 (CD106) on human umbilical vein endothelial cells (HUVEC), both on mRNA and protein level. All three proteins are essential for the initial steps of lymphocyte recruitment to inflamed tissues. Treatment with dimethylfumarate concentrations ranging between 25	de
dc.contributor.coReferee	Crozier, Thomas Prof. Dr. Dr.	de
dc.subject.topic	Medicine	de
dc.subject.ger	Psoriasis	de
dc.subject.ger	Endothelzellen	de
dc.subject.ger	Fumarsäureester	de
dc.subject.ger	Lymphozyten	de
dc.subject.ger	Entzündung	de
dc.subject.eng	psoriasis	de
dc.subject.eng	endothelial cells	de
dc.subject.eng	fumaric acid esters	de
dc.subject.eng	lymphocytes	de
dc.subject.eng	inflammation	de
dc.subject.bk	44.93	de
dc.subject.bk	44.45	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-3606-6	de
dc.identifier.purl	webdoc-3606	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.description.embargoed	2013-11-30	de
dc.identifier.ppn	773354867

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Human- und Zahnmedizin [2873]

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