dc.contributor.advisor | Nitsche, Michael Prof. Dr. | de |
dc.contributor.author | Sturhan, Cornelia-Carmen | de |
dc.date.accessioned | 2013-01-14T15:27:40Z | de |
dc.date.available | 2013-01-30T23:50:52Z | de |
dc.date.issued | 2012-07-16 | de |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-000D-EFE2-3 | de |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-1571 | |
dc.description.abstract | Hintergrund: Ein Verfahren, um kortikale
Erregbarkeit und Aktivität zu verändern besteht in der
transkraniellen Stimulation des Motorkortex mit schwachem
Gleichstrom (tDCS). Dabei erhöht anodale und reduziert kathodale
Stimulation mit tDCS über dem primärmotorischen Kortex dessen
Exzitabilität. Pharmakologisch wurde bereits die Abhängigkeit der
durch kurz andauernde Stromstimulation bedingten Effekte von der
Aktivität der Natrium- und Calciumkanäle identifiziert. Auf dieser
Grundlage wurden in dieser Arbeit die genaueren
neurophysiologischen Zusammenhänge mit der Frage nach dem Ursprung
der Erregbarkeitsänderungen während tDCS untersucht. Methoden:
Abhängig vom Untersuchungsprotokoll wurden die Versuche an 12- 20
Probanden durchgeführt. tDCS erfolgte wiederholt für eine Dauer von
4 Sekunden. Die Exzitabilitätsänderungen wurden mittels
transkranieller Magnestimulation (TMS) erfasst. In verschiedenen
Protokollen wurden die Exzitabilität des kortikospinalen
Kerngebietes durch die Bestimmung der motorischen Schwellen, die
Aktivität größerer Neuronenpopulationen durch die Bestimmung der
Rekrutierungskurve, | de |
dc.format.mimetype | application/pdf | de |
dc.language.iso | ger | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | de |
dc.title | Akute Auswirkungen transkranieller Gleichstromstimulation auf Parameter kortikaler Erregbarkeit | de |
dc.type | doctoralThesis | de |
dc.title.translated | Acute effects of transcranial direct current stimulation on cortical excitability parameters | de |
dc.contributor.referee | Hülsmann, Michael Prof. Dr. | de |
dc.date.examination | 2012-07-24 | de |
dc.subject.dnb | 610 Medizin, Gesundheit | de |
dc.subject.gok | med 311 | de |
dc.description.abstracteng | Background: Non-invasive brain stimulation
with weak direct currents (transcranial direct current stimulation,
tDCS) enables the alteration of cortical activity and excitability
of the human brain. It has been demonstrated that the effects of
short-lasting tDCS, which induces no after-effects, depend on the
activity of voltage-gated sodium and calcium channels.The aim of
this study was to find out more about the neurophysiological origin
of the tDCS-generated excitability changes. Methods: Depending on
the stimulation protocol, the experiments were carried out in 12-20
healthy volunteers. tDCS was repetitively applied for a duration of
4 seconds. Cortico-spinal and intracortical excitability
alterations were explored by transcranial magnetic stimulation
(TMS). Specifically, the excitability of the corticospinal core
area was explored by determination of motor thresholds, the
activity of larger neuronal populations by the recruitment curve,
and intracortical effects by short latency intracortical
inhibition, intracortical facilitation, and I-wave facilitation.
Results: For the corticospinal measures, tDCS elicited no
alterations of motor thresholds, but anodal tDCS increased
trendwise the slope of the recruitment curve, while cathodal tDCS
diminished it. Significant changes of intracortical excitability
were only revealed during cathodal tDCS at an interstimulus
interval of 15 ms, showing reduced intracortical facilitation.
Conclusion: tDCS affects corticospinal excitability, as shown by
its impact on the recruitment curves. The diminution of
intracortical facilitation during cathodal stimulation is might be
caused by an additional alteration of NMDA receptors. The missing
effects of tDCS on I-wave-activity and other parameters of
intracortical facilitation and inhibition, which are all based on
GABAergic und glutamatergic mechanisms, confirms the concept that
the primary effects of tDCS are changes in membrane
polarization | de |
dc.contributor.coReferee | Brockmann, Knut Prof. Dr. | de |
dc.subject.topic | Medicine | de |
dc.subject.ger | Transkranielle Gleichstromstimulation | de |
dc.subject.ger | tDCS | de |
dc.subject.ger | TMS | de |
dc.subject.ger | kortikale Erregbarkeit | de |
dc.subject.ger | Motorische Schwellen | de |
dc.subject.ger | Input-ouput-Kurve | de |
dc.subject.ger | I-waves | de |
dc.subject.ger | Inhibition | de |
dc.subject.ger | Fazilitierung | de |
dc.subject.eng | Weak direct current stimulation | de |
dc.subject.eng | tDCS | de |
dc.subject.eng | TMS | de |
dc.subject.eng | cortical excitabilty | de |
dc.subject.eng | motor thresholds | de |
dc.subject.eng | input output curve | de |
dc.subject.eng | i-waves | de |
dc.subject.eng | inhibition | de |
dc.subject.eng | facilitation | de |
dc.subject.bk | 44.97 | de |
dc.subject.bk | 44.37 | de |
dc.subject.bk | 44.90 | de |
dc.identifier.urn | urn:nbn:de:gbv:7-webdoc-3614-0 | de |
dc.identifier.purl | webdoc-3614 | de |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.identifier.ppn | 728919648 | de |