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Etablierung eines Messverfahrens für die Komplementkomponente FHR-3 und seine Anwendung auf die Bestimmung von FHR-3 Plasmakonzentrationen bei Patienten mit altersabhängiger Makuladegeneration.

Establishment of a measurement procedure for the complement FHR-3 and its application to the determination of FHR-3 plasma concentrations in patients with age-related macular degeneration.

by Daniela Och
Doctoral thesis
Date of Examination:2012-08-01
Date of issue:2012-07-19
Advisor:Prof. Dr. Martin Oppermann
Referee:PD Dr. Michael Koziolek
Referee:PD Dr. Michael Koziolek
Referee:PD Dr. Michael Koziolek
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-1575

 

 

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Abstract

English

Production and epitope analysis of monoclonal antibodies against the complement FHR-3, where a sandwich ELISA was established, the plasma concentration and a deficiency of FHR-3 to determine in patients with age-related macular degeneration.
Keywords: age-related macular degeneration; FHR-3; complement system; monoclonal antibodies; factor H family

Other Languages

Herstellung und Epitopanalyse von monoklonalen Antikörpern gegen den Komplementfaktor FHR-3, mit denen ein Sandwich-ELISA etabliert werden konnte, um die Plasmakonzentration sowie eine Defizienz von FHR-3 bei Patienten mit altersabhängiger Makuladegeneration zu bestimmen.
Schlagwörter: altersbedingte Makuladegeneration; FHR-3; Komplementsystem; monoklonale Antikörper; Faktor H Familie
 

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