Untersuchungen zur Regulation der Zelladhäsion durch PHD2 in Tumorzellen
Investigation on the role of PHD2 in the regulation of cell adhesion in tumor cells
by Moritz Thomas Schnelle
Date of Examination:2012-08-14
Date of issue:2012-07-24
Advisor:Prof. Dr. Dörthe Katschinski
Referee:Prof. Dr. Dörthe Katschinski
Referee:Prof. Dr. Matthias Dobbelstein
Referee:Prof. Dr. Martin Oppermann
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Abstract
English
The hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which is stabilized under hypoxic conditions. It consists of the HIF-1β- as well as of one of three known HIF-α-subunits. One of its
Keywords: hypoxia; PHD2; HIF-1α; cell adhesion; metastasation; SPARC; SPP1; cofilin
Schlagwörter: Hypoxie; PHD2; HIF-1α; Zelladhäsion; Metastasierung; SPARC; SPP1; Cofilin