Mechanismen Isoprenalin-induzierter Extrakontraktionen im humanen Vorhofmyokard

Mechanismen Isoprenalin-induzierter Extrakontraktionen im humanen Vorhofmyokard

Mechanisms of isoprenaline-induced extra contractions in human atrial myocardium

Dörte Schottky

Doctoral thesis

Date of Examination: 2012-07-31

Date of issue: 2012-07-27

Advisor: Kockskämper, Jens Prof. Dr.

Referee: Kockskämper, Jens Prof. Dr.

Referee: Seipelt, Ralf PD Dr.

Referee: Oppermann, Martin Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-000D-EFEE-B

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Abstract

English

Defective regulation of Ca2+-homeostasis and, more particularly, the release of Ca2+ through the ryanodine receptor (RyR2) of the sarcoplasmic reticulum plays a crucial role in the occurrence of cardiac arrhythmias. The ryanodine receptor may be phosphorylated following

Keywords: ryanodine receptor; PKA; CaMKII; arrhythmia; β-adrenergic stimulation; atrial myocardium

Schlagwörter: Ryanodinrezeptor; PKA; CaMKII; Arrhythmie; β-adrenerge Stimulation; Vorhofmyokard