Mechanismen Isoprenalin-induzierter Extrakontraktionen im humanen Vorhofmyokard

Mechanisms of isoprenaline-induced extra contractions in human atrial myocardium

by Dörte Schottky
Doctoral thesis
Date of Examination:2012-07-31
Date of issue:2012-07-27
Advisor:Prof. Dr. Jens Kockskämper
Referee:Prof. Dr. Jens Kockskämper
Referee:PD Dr. Ralf Seipelt
Referee:Prof. Dr. Martin Oppermann
Persistent Address: http://dx.doi.org/10.53846/goediss-1583

 

 

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Abstract

English

Defective regulation of Ca2+-homeostasis and, more particularly, the release of Ca2+ through the ryanodine receptor (RyR2) of the sarcoplasmic reticulum plays a crucial role in the occurrence of cardiac arrhythmias. The ryanodine receptor may be phosphorylated following
Keywords: ryanodine receptor; PKA; CaMKII; arrhythmia; β-adrenergic stimulation; atrial myocardium
Schlagwörter: Ryanodinrezeptor; PKA; CaMKII; Arrhythmie; β-adrenerge Stimulation; Vorhofmyokard
 
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