As part of the study was to investigate
whether the nephro-protective effect of endothelial progenitor
cells can be enhanced by pretreatment of cells with melatonin. In
animal experiments, the left kidney of experimental mice was
exposed to a renal ischemia of 40 minutes. After ischemia the
appropriate solution (corresponding to the respective group) was
injected into the vessel of the contralateral kidney which was
removed afterwards. Therefore the complete renal function has been
taken over from the pre-damaged ischemic kidney. A statement on the
renal function was made on the basis of creatinine in blood after
two days. The renal damage was assessed microscopically in paraffin
sections and evaluated semi-quantitatively. There are four groups
studied, and the creatinine was compared to a control group. The
animals of the first group was injected 50
