Zytogenetische Charakterisierung der Glioblastomzelllinie G112 in Bezug auf tumorstammzellähnliche Eigenschaften und Strahlentherapie

Cytogenetic Characterisation Of Glioblastoma Cell Line G112 Concerning Tumor Stem Cell Like Properties And Radiotherapy

by Marina Rippl
Doctoral thesis
Date of Examination:2013-01-07
Date of issue:2013-01-09
Advisor:PD Dr. Bastian Gunawan
Advisor:PD Dr. Ella Kim
Referee:PD Dr. Bastian Gunawan
Referee:Prof. Dr. Detlef Haase
Referee:Prof. Dr. Patricia Virsik-Köpp
Persistent Address: http://dx.doi.org/10.53846/goediss-1666

 

 

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Abstract

English

The glioblastoma multiforme (GBM) is the most frequent and the most malignant brain tumor showing the highest rate of anaplasia (WHO Grade IV) (Riede and Schaefer 2001b). The prognosis is bad (Mueller 2006) despite multi-modal and evergrowing new methods of treatment (Omay and Vogelbaum 2009; Mueller 2006; Weller 2008; Fukushima et al. 2009; Tabatabai and Stupp 2010). Many hypotheses about the origin of GBM are being discussed (Reya et al. 2001). The “GBM-Stem-Cell-Model
Keywords: Glioblastoma multiforme; Cell-line G112; Brain Tumor Initiating Cells; Radiotherapy; Cell culture; Cytogenetical Differences
Schlagwörter: Glioblastoma multiforme; Zelllinie G112; Tumorstammzellhypothese; Strahlentherapie; Zellkultur; Chromosomenanalyse
 
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