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Modeling the biophysical mechanisms of sound encoding at inner hair cell ribbon synapses

dc.contributor.advisorWolf, Fred Prof. Dr.de
dc.contributor.authorChapochnikov, Nikolaide
dc.date.accessioned2012-11-28T15:59:54Zde
dc.date.accessioned2013-01-18T13:40:41Zde
dc.date.available2013-01-30T23:51:12Zde
dc.date.issued2012-11-28de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-000D-F092-3de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-2898
dc.format.mimetypeapplication/pdfde
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de
dc.titleModeling the biophysical mechanisms of sound encoding at inner hair cell ribbon synapsesde
dc.typedoctoralThesisde
dc.title.translatedModellierung der biophysikalischen Mechanismen der Schallkodierung an Bandsynapsen der inneren Haarzellende
dc.contributor.refereeWolf, Fred Prof. Dr.de
dc.date.examination2011-12-15de
dc.subject.dnb570 Biowissenschaftende
dc.subject.dnbBiologiede
dc.subject.gokWXG 900de
dc.subject.gokWC000de
dc.description.abstractengA key stage in auditory encoding is the transformation of the analog and continuous electrical signal at inner hair cells (IHCs) into the discrete spike timings in auditory nerve fibers (ANFs). In this work, using modeling, we investigated the biophysical specializations of the IHC ribbon synapse, which support this transcoding of the auditory signal. First, in combination with experiments, we studied the coupling of the ANF postsynaptic bouton to its action potential generator. We found that ANFs encode with submillisecond precision the timings of neurotransmitter release from IHCs. Then, we investigated the sound signal encoding at the presynapse. By modeling vesicle diffusion on the synaptic ribbon, we show that the ribbon might act as a “Brownian conveyor trapde
dc.contributor.coRefereeMoser, Tobias Prof. Dr.de
dc.contributor.thirdRefereeGail, Alexander Prof. Dr.de
dc.subject.topicPhysicsde
dc.subject.gerHörschneckede
dc.subject.gerHaarzellede
dc.subject.gerHörnervenfasernde
dc.subject.gerBändersynapsede
dc.subject.gersynaptische Transmissionde
dc.subject.gerAktionspotentialde
dc.subject.gerIntegrate-and-Fire-Neuronde
dc.subject.gerModellierungde
dc.subject.gerKodierungde
dc.subject.gerComputational Neurosciencede
dc.subject.engcochleade
dc.subject.enghair cellde
dc.subject.engauditory nerve fibersde
dc.subject.engribbon synapsede
dc.subject.engsynaptic transmissionde
dc.subject.engaction potentialde
dc.subject.engintegrate-and-fire neuronde
dc.subject.engmodelingde
dc.subject.engcodingde
dc.subject.engcomputational neurosciencede
dc.subject.bk42.12de
dc.subject.bk42.15de
dc.subject.bk42.63de
dc.identifier.urnurn:nbn:de:gbv:7-webdoc-3815-6de
dc.identifier.purlwebdoc-3815de
dc.affiliation.instituteFakultät für Physikde
dc.identifier.ppn737899131de


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