Modeling the biophysical mechanisms of sound encoding at inner hair cell ribbon synapses

Chapochnikov, Nikolai

dc.contributor.advisor	Wolf, Fred Prof. Dr.	de
dc.contributor.author	Chapochnikov, Nikolai	de
dc.date.accessioned	2012-11-28T15:59:54Z	de
dc.date.accessioned	2013-01-18T13:40:41Z	de
dc.date.available	2013-01-30T23:51:12Z	de
dc.date.issued	2012-11-28	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F092-3	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-2898
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Modeling the biophysical mechanisms of sound encoding at inner hair cell ribbon synapses	de
dc.type	doctoralThesis	de
dc.title.translated	Modellierung der biophysikalischen Mechanismen der Schallkodierung an Bandsynapsen der inneren Haarzellen	de
dc.contributor.referee	Wolf, Fred Prof. Dr.	de
dc.date.examination	2011-12-15	de
dc.subject.dnb	570 Biowissenschaften	de
dc.subject.dnb	Biologie	de
dc.subject.gok	WXG 900	de
dc.subject.gok	WC000	de
dc.description.abstracteng	A key stage in auditory encoding is the transformation of the analog and continuous electrical signal at inner hair cells (IHCs) into the discrete spike timings in auditory nerve fibers (ANFs). In this work, using modeling, we investigated the biophysical specializations of the IHC ribbon synapse, which support this transcoding of the auditory signal. First, in combination with experiments, we studied the coupling of the ANF postsynaptic bouton to its action potential generator. We found that ANFs encode with submillisecond precision the timings of neurotransmitter release from IHCs. Then, we investigated the sound signal encoding at the presynapse. By modeling vesicle diffusion on the synaptic ribbon, we show that the ribbon might act as a “Brownian conveyor trap	de
dc.contributor.coReferee	Moser, Tobias Prof. Dr.	de
dc.contributor.thirdReferee	Gail, Alexander Prof. Dr.	de
dc.subject.topic	Physics	de
dc.subject.ger	Hörschnecke	de
dc.subject.ger	Haarzelle	de
dc.subject.ger	Hörnervenfasern	de
dc.subject.ger	Bändersynapse	de
dc.subject.ger	synaptische Transmission	de
dc.subject.ger	Aktionspotential	de
dc.subject.ger	Integrate-and-Fire-Neuron	de
dc.subject.ger	Modellierung	de
dc.subject.ger	Kodierung	de
dc.subject.ger	Computational Neuroscience	de
dc.subject.eng	cochlea	de
dc.subject.eng	hair cell	de
dc.subject.eng	auditory nerve fibers	de
dc.subject.eng	ribbon synapse	de
dc.subject.eng	synaptic transmission	de
dc.subject.eng	action potential	de
dc.subject.eng	integrate-and-fire neuron	de
dc.subject.eng	modeling	de
dc.subject.eng	coding	de
dc.subject.eng	computational neuroscience	de
dc.subject.bk	42.12	de
dc.subject.bk	42.15	de
dc.subject.bk	42.63	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-3815-6	de
dc.identifier.purl	webdoc-3815	de
dc.affiliation.institute	Fakultät für Physik	de
dc.identifier.ppn	737899131	de

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