Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory

Kerimoglu, Cemil

dc.contributor.advisor	Fischer, André Prof. Dr.	de
dc.contributor.author	Kerimoglu, Cemil	de
dc.date.accessioned	2012-06-06T18:34:54Z	de
dc.date.accessioned	2013-01-18T14:23:45Z	de
dc.date.available	2013-01-30T23:51:09Z	de
dc.date.issued	2012-06-06	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F0B4-8	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3197
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3197
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory	de
dc.type	doctoralThesis	de
dc.title.translated	Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory	de
dc.contributor.referee	Fischer, André Prof. Dr.	de
dc.date.examination	2012-04-16	de
dc.subject.dnb	500 Naturwissenschaften	de
dc.subject.gok	RA 000	de
dc.description.abstracteng	Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. Although the role of histone acetylation and different histone deacetylases (HDACs) and histone acetyltransferases (HATs) in learning and memory has been studied quite extensively, the knowledge concerning the role of histone methylation – another important histone modification – in learning and memory is lacking. I have characterized the transgenic mouse line in which the Mll2 gene is conditionally knocked down at adult stage in the forebrain excitatory neurons by the Cre-LoxP system, with Cre recombinase being expressed under CamKII promoter in order to ensure recombination specifically in forebrain glutamatergic neurons knock-out mice being denoted as “F/F CKII	de
dc.contributor.coReferee	Stühmer, Walter Prof. Dr.	de
dc.contributor.thirdReferee	Fischle, Wolfgang Prof. Dr.	de
dc.subject.topic	Göttingen Graduate School for Neurosciences and Molecular Biosciences (GGNB)	de
dc.subject.ger	Mll2	de
dc.subject.ger	Histone Methylierung	de
dc.subject.ger	Lernen	de
dc.subject.ger	Gedächtnis	de
dc.subject.eng	Mll2	de
dc.subject.eng	Histone Methylation	de
dc.subject.eng	Learning	de
dc.subject.eng	Memory	de
dc.subject.bk	30.00	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-3545-7	de
dc.identifier.purl	webdoc-3545	de
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften und Molekulare Biowissenschaften (GGNB)	de
dc.identifier.ppn	737899395	de

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Das Dokument erscheint in:

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1114]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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