Comparative studies on regulation of SNARE complex formation by the SM protein Sly1p

Vergleichende Studien zur Regulation der SNARE Komplex Bildung durch das SM protein Sly1p

by Fatma Esra Demircioglu
Doctoral thesis
Date of Examination:2011-11-01
Date of issue:2012-06-11
Advisor:Prof. Dr. Dirk Fasshauer
Referee:Prof. Dr. Dirk Fasshauer
Referee:Prof. Dr. Markus Wahl
Referee:Prof. Dr. Stefan Eimer
Persistent Address: http://dx.doi.org/10.53846/goediss-3262

 

 

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Abstract

English

Sec1/ Munc18 (SM) proteins are indispensible regulators of intracellular membrane fusion. In general, the high-affinity binding partners of SM proteins are Qa-SNAREs (syntaxins). Despite the high structural homology among SM proteins, different modes are proposed for their association with syntaxins. Neuronal Munc18a binds to a ‟closed conformation
Keywords: Membrane fusion; Sly1p; SNARE; syntaxin; Sed5p; ER; Golgi
Schlagwörter: Membranfusion; Sly1p; SNARE; Syntaxin; Sed5p; ER; Golgi
 
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