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Das synaptische Vesikelrecycling: Molekulare Funktionen des AP-1-Komplexes und seiner σ1B-Adaptinuntereinheit

Synaptic vesicle recycling: Molecular functions of the AP-1 complex subunit σ1B-adaptin

Manuel Kratzke
Doctoral thesis
Date of Examination: 2012-09-11
Date of issue: 2012-09-26
Advisor: Schu, Peter Prof. Dr.
Referee: Schu, Peter Prof. Dr.
Referee: Steinem, Claudia Prof. Dr.
Referee: Wienands, Jürgen Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-000D-F0BE-3

 

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Abstract

English

The heterotetrameric AP-1-complex is localized to trans-Golgi-Network (TGN) and early endosomes. It mediates specific clathrin-dependant vesicular pathways. In vertebrates three isoforms of its σ1 subunit are expressed: A, B and C. σ1A is ubiquitously expressed, while σ1B and σ1C are expressed in a tissue specific pattern. σ1B shows highest expression in brain. The phenotype of AP-1/σ1B-
Keywords: adaptor protein complex; clathrin; sigma1B; synaptic vesicles; early endosomes
Schlagwörter: Adaptor Protein Komplex; Clathrin; sigma1B; synaptische Vesikel; frühe Endosomen
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