Identification of nuclear export signals and structural analysis of transport complexes.

Identification of nuclear export signals and structural analysis of transport complexes.

von Chandini Kadian
Dissertation
Datum der mündl. Prüfung:2012-09-21
Erschienen:2013-01-09
Betreuer:Prof. Dr. Dirk Görlich
Gutachter:Prof. Dr. Dirk Görlich
Gutachter:Prof. Dr. Marina Rodnina
Gutachter:Prof. Dr. Ralf Ficner
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-3193

 

 

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Zusammenfassung

Englisch

The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and controlled process. Facilitated transport processes are executed by Nuclear Transport Receptors (NTR). The goals of my doctoral work have been divided in two broad themes, which have been summarized below. Identification of Nuclear Export Signals for CRM1 mediated export: The nucleus is specialised in transcription and the cytosol is specialised in translation. Nuclear translation is not permitted, because translation of unspliced transcripts could lead to a formation of misfolded or possibly lethal proteins. Exclusion of translation factors is one of the methods employed by the cell to prohibit nuclear translation. eIF2
Keywords: Nucleocytoplasmic transport
 
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