Identification of nuclear export signals and structural analysis of transport complexes.

Identification of nuclear export signals and structural analysis of transport complexes.

by Chandini Kadian
Doctoral thesis
Date of Examination:2012-09-21
Date of issue:2013-01-09
Advisor:Prof. Dr. Dirk Görlich
Referee:Prof. Dr. Dirk Görlich
Referee:Prof. Dr. Marina Rodnina
Referee:Prof. Dr. Ralf Ficner
Persistent Address: http://dx.doi.org/10.53846/goediss-3193

 

 

Files in this item

Name:kadian.pdf
Size:8.55Mb
Format:PDF

The following license files are associated with this item:

Abstract

English

The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and controlled process. Facilitated transport processes are executed by Nuclear Transport Receptors (NTR). The goals of my doctoral work have been divided in two broad themes, which have been summarized below. Identification of Nuclear Export Signals for CRM1 mediated export: The nucleus is specialised in transcription and the cytosol is specialised in translation. Nuclear translation is not permitted, because translation of unspliced transcripts could lead to a formation of misfolded or possibly lethal proteins. Exclusion of translation factors is one of the methods employed by the cell to prohibit nuclear translation. eIF2
Keywords: Nucleocytoplasmic transport
 
Statistik