dc.contributor.advisor | Görlich, Dirk Prof. Dr. | de |
dc.contributor.author | Kadian, Chandini | de |
dc.date.accessioned | 2013-01-09T18:37:52Z | de |
dc.date.accessioned | 2013-01-18T14:23:36Z | de |
dc.date.available | 2013-03-20T23:50:04Z | de |
dc.date.issued | 2013-01-09 | de |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-000D-F0CD-1 | de |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-3193 | |
dc.format.mimetype | application/pdf | de |
dc.language.iso | eng | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | de |
dc.title | Identification of nuclear export signals and structural analysis of transport complexes. | de |
dc.type | doctoralThesis | de |
dc.title.translated | Identification of nuclear export signals and structural analysis of transport complexes. | de |
dc.contributor.referee | Görlich, Dirk Prof. Dr. | de |
dc.date.examination | 2012-09-21 | de |
dc.subject.dnb | 500 Naturwissenschaften | de |
dc.subject.gok | WF 200 Molekularbiologie | de |
dc.description.abstracteng | The nucleus is a vital sub cellular
compartment and it stores the genome. Transport across the nuclear
envelope occurs through Nuclear Pore Complexes (NPC) and cargo
traffic across the NPCs is a highly specific and controlled
process. Facilitated transport processes are executed by Nuclear
Transport Receptors (NTR). The goals of my doctoral work have been
divided in two broad themes, which have been summarized below.
Identification of Nuclear Export Signals for CRM1 mediated export:
The nucleus is specialised in transcription and the cytosol is
specialised in translation. Nuclear translation is not permitted,
because translation of unspliced transcripts could lead to a
formation of misfolded or possibly lethal proteins. Exclusion of
translation factors is one of the methods employed by the cell to
prohibit nuclear translation. eIF2 | de |
dc.contributor.coReferee | Rodnina, Marina Prof. Dr. | de |
dc.contributor.thirdReferee | Ficner, Ralf Prof. Dr. | de |
dc.subject.topic | Göttingen Graduate School for Neurosciences and Molecular Biosciences (GGNB) | de |
dc.subject.eng | Nucleocytoplasmic transport | de |
dc.subject.bk | 42.13 Molekularbiologie | de |
dc.subject.bk | 42.15 Zellbiologie | de |
dc.identifier.urn | urn:nbn:de:gbv:7-webdoc-3865-4 | de |
dc.identifier.purl | webdoc-3865 | de |
dc.affiliation.institute | Göttinger Graduiertenschule für Neurowissenschaften und Molekulare Biowissenschaften (GGNB) | de |
dc.description.embargoed | 2013-03-20 | de |
dc.identifier.ppn | 739325612 | de |