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Identification of nuclear export signals and structural analysis of transport complexes.

dc.contributor.advisorGörlich, Dirk Prof.
dc.contributor.authorKadian, Chandinide
dc.titleIdentification of nuclear export signals and structural analysis of transport
dc.title.translatedIdentification of nuclear export signals and structural analysis of transport
dc.contributor.refereeGörlich, Dirk Prof.
dc.subject.dnb500 Naturwissenschaftende
dc.subject.gokWF 200 Molekularbiologiede
dc.description.abstractengThe nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and controlled process. Facilitated transport processes are executed by Nuclear Transport Receptors (NTR). The goals of my doctoral work have been divided in two broad themes, which have been summarized below. Identification of Nuclear Export Signals for CRM1 mediated export: The nucleus is specialised in transcription and the cytosol is specialised in translation. Nuclear translation is not permitted, because translation of unspliced transcripts could lead to a formation of misfolded or possibly lethal proteins. Exclusion of translation factors is one of the methods employed by the cell to prohibit nuclear translation. eIF2de
dc.contributor.coRefereeRodnina, Marina Prof.
dc.contributor.thirdRefereeFicner, Ralf Prof.
dc.subject.topicGöttingen Graduate School for Neurosciences and Molecular Biosciences (GGNB)de
dc.subject.engNucleocytoplasmic transportde
dc.subject.bk42.13 Molekularbiologiede
dc.subject.bk42.15 Zellbiologiede
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften und Molekulare Biowissenschaften (GGNB)de

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