Botulinumtoxin-Typ A - eine Therapieoption bei überaktiven und nicht-neurogenen Blasenentleerungsstörungen (retrospektive Datenanalyse)

Botulinum toxin type A - a treatment option for overactive and non-neurogenic detrusor overactivity (retrospective study)

by Katharina Zachert
Doctoral thesis
Date of Examination:2010-01-10
Date of issue:2009-11-11
Advisor:PD Dr. Hagen Loertzer
Referee:PD Dr. Hagen Loertzer
Persistent Address: http://dx.doi.org/10.53846/goediss-3346

 

 

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Abstract

English

Objectives: Since the first therapeutic applications of botulinum toxin about 20 years ago, it has become an effective treatment for various indications including overactive and non-neurogenic detrusor overactivity. Synthesized in Clostridium botulinum, the neurotoxin inhibits the acetylcholine secretion leading to a paralysis when injected into the detrusor muscle with both urodynamic and clinical improvements. This minimally invasive treatment is positioned between ineffective anticholinergic treatment and invasive surgery. The present retrospective study examined the effectiveness of transurethral injections of botulinum toxin given in the Department of Urology, University of Goettingen. Methods: Patients (n=32) with overactive and non-neurogenic detrusor overactivity received 88 injections of botulinum toxin type A in 13 injection cycles from February 2002 until October 2008. The effects on urodynamic and clinical parameters were analyzed. Also four injection protocols for future applications were created. Results: In most cases 300 units of Botox
Keywords: Botulinum toxin type A; detrusor overactivity; urodynamic parameters
Schlagwörter: Botulinumtoxin-Typ A; Blasenentleerungsstörungen; urodynamische Parameter
 
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